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Electrochemical study for the effect of simvastatin and atorvastatin on coenzyme Q10 by differential pulse polarography using mercury drop electrode
Other Title(s)
دراسة كهروكيميائية لتأثر السيمفاستاتين و الأتورفاستاتين مع مساعد الأنزيم Q10 بواسطة البولاروغرافيا المشتقة باستخدام قطب الزئبق المتقاطر
Author
al-Asadi, Sahil Abd al-Husayn Ghafuri
Source
Issue
Vol. 56, Issue 3A (31 Mar. 2015), pp.1811-1820, 10 p.
Publisher
University of Baghdad College of Science
Publication Date
2015-03-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
-Statin drugs act by inhibiting the enzyme HMG-CoA reductase which is responsible for manufacture of cholesterol and the biosynthesis essential energy production Co-factor (Coenzyme Q10).
The aim from this research includes study the effect of statin drugs (Simvastatin and Atorvastatin) on the Coenzyme Q10 using differential pulse polarographic technique at a dropping mercury electrode (DME) and in a mixture of [4:1] methanol-phosphate buffer of pH7.0 as supporting an electrolyte.
Prior to this, the behaviors of Simvastatin, Atorvastatin and Coenzyme Q10 were studied separately in their solvents.
The half-wave potential (E1/2) of Co Q10 were -0.31volt and -1.37Volt, -1.33 Volt for simvastatin and atorvastatin respectively.
A mixture of Coenzyme Q10 with Simvastatin and Atorvastatin in the same solvent shows a shift in their peak potential (Ep) toward more negative potentials values by (-0.06volt) for Simvastatin and by (-0.09volt) by Atorvastatin
American Psychological Association (APA)
al-Asadi, Sahil Abd al-Husayn Ghafuri. 2015. Electrochemical study for the effect of simvastatin and atorvastatin on coenzyme Q10 by differential pulse polarography using mercury drop electrode. Iraqi Journal of Science،Vol. 56, no. 3A, pp.1811-1820.
https://search.emarefa.net/detail/BIM-622369
Modern Language Association (MLA)
al-Asadi, Sahil Abd al-Husayn Ghafuri. Electrochemical study for the effect of simvastatin and atorvastatin on coenzyme Q10 by differential pulse polarography using mercury drop electrode. Iraqi Journal of Science Vol. 56, no. 3A (2015), pp.1811-1820.
https://search.emarefa.net/detail/BIM-622369
American Medical Association (AMA)
al-Asadi, Sahil Abd al-Husayn Ghafuri. Electrochemical study for the effect of simvastatin and atorvastatin on coenzyme Q10 by differential pulse polarography using mercury drop electrode. Iraqi Journal of Science. 2015. Vol. 56, no. 3A, pp.1811-1820.
https://search.emarefa.net/detail/BIM-622369
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-622369