Diazotised suhphanilic acid reagent for the determination of trace amounts of cephadroxil in aqueous solution : application to pharmaceutical preparations
Joint Authors
Umar, Shilan Ali
Uthman, Nabil Subayh
Source
al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah
Issue
Vol. 21, Issue 3 (30 Sep. 2008), pp.23-33, 11 p.
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2008-09-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
A simple spectrophotometric method for the determination of cephadroxil in aqueous solution is developed.
The method is based on the coupling of cephadroxil with diazotised sulphanilic acid reagent in the presence of sodium hydroxide.
The yellow azo-dye formed is water– soluble, stable, and shows maximum absorption at 445 nm.
Beer’s law is obeyed over the range 10–240 μg/25 ml (0.4 –9.6 ppm) with a molar absorptivity of 1.73×104 l.mol-1cm-1, Sandell’s sensitivity index of 0.0210 μg/cm2, a relative error of –0.42 to +2.22 % and a relative standard deviation of ± 1.7 to ± 2.4 %, depending on the concentration level.
The composition of the yellow azo-dye has been evaluated.
The proposed method has been successfully applied to the determination of cephadroxil in various pharmaceutical preparations.
American Psychological Association (APA)
Uthman, Nabil Subayh& Umar, Shilan Ali. 2008. Diazotised suhphanilic acid reagent for the determination of trace amounts of cephadroxil in aqueous solution : application to pharmaceutical preparations. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 21, no. 3, pp.23-33.
https://search.emarefa.net/detail/BIM-623101
Modern Language Association (MLA)
Uthman, Nabil Subayh& Umar, Shilan Ali. Diazotised suhphanilic acid reagent for the determination of trace amounts of cephadroxil in aqueous solution : application to pharmaceutical preparations. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 21, no. 3 (Sep. 2008), pp.23-33.
https://search.emarefa.net/detail/BIM-623101
American Medical Association (AMA)
Uthman, Nabil Subayh& Umar, Shilan Ali. Diazotised suhphanilic acid reagent for the determination of trace amounts of cephadroxil in aqueous solution : application to pharmaceutical preparations. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2008. Vol. 21, no. 3, pp.23-33.
https://search.emarefa.net/detail/BIM-623101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 32-33
Record ID
BIM-623101