Ways of treating IgA nephropathies

Abstract EN

Treatment options for IgA nephropathy (IgAN) must take into consideration the pathophysiology, namely the role of eicosanoids, angiotensin II and monocytemacrophages releasing reactive oxygen species (ROS).

Angiotensin converting enzyme inhibitors and early corticosteroid usage are prime therapies.

Tonsillectomy should be considered.

Other components of a therapeutic cocktail could be ; (a) thromboxane antogonist, (b) leukotriene antagonist, (c) platelet activating factor antagonist, (d) an antioxidant and (e) an anti-fibrotic agent like pentoxyfylline.

In the new millenium, there will be focus on anti-proliferative measures like platelets dependent growth factor aptamers.

For unusual cases with rapid progression, the use of FK-506 or mycophenolate mofetil can be considered.