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Long-term outcome of adult onset idiopathic minimal change disease
Joint Authors
Korbet, Stephen M.
Colattur, Shyam N.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 11, Issue 3 (30 Jun. 2000), pp.334-344, 11 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2000-06-30
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Topics
- Adults
- Patients
- Kidneys
- Diseases
- Complications(Medicine)
- Kidney failure
- Nephrotic syndrome
- Kidney glomerulus
Abstract EN
Minimal Change Disease (MCD) is the lesion most commonly associated with nephrotic syndrome in children, accounting for over 75 % of cases.
Although less common, MCD still accounts for up to 30 % of adult onset nephrotic syndrome.
Unlike children, in whom MCD is primarily idiopathic, secondary causes of MCD are seen in 13 % of adults and must be considered, as the therapeutic approach to these patients is defined by the underlying cause.
Clinical features at presentation in nephrotic adults with MCD can include microscopic hematuria, hypertension, and renal insufficiency, making MCD indistinguishable clinically from focal segmental glomerulosclerosis.
As a result, a renal biopsy is required in adults in order to correctly diagnose and manage the nephrotic syndrome.
As in children, response to therapy leads to a complete remission of proteinuria in up to 97 % of adults, although, adults require a more prolonged course of therapy (16-28 weeks) compared to children (8 weeks).
Relapse of MCD is extremely common in children (71 %) and can be seen in up to 85 % of adult patients.
Relapses occur more frequently in younger adults (< 45 years) and are often seen in the first 6-12 months after the onset of a remission.
Successful treatment of relapses can often be achieved with a second course of steroids.
However, up to 50 % of relapsing adults become frequent relapsers or steroid dependent.
In these patients, a stable remission can be induced by treatment with either cyclophosphamide or cyclosporine.
Overall, the long-term outcome of adult onset MCD is excellent, with fewer than 5 % of patients progressing to end-stage renal disease and a patient survival of 83 %-98 % at 15 years.
American Psychological Association (APA)
Colattur, Shyam N.& Korbet, Stephen M.. 2000. Long-term outcome of adult onset idiopathic minimal change disease. Saudi Journal of Kidney Diseases and Transplantation،Vol. 11, no. 3, pp.334-344.
https://search.emarefa.net/detail/BIM-62611
Modern Language Association (MLA)
Colattur, Shyam N.& Korbet, Stephen M.. Long-term outcome of adult onset idiopathic minimal change disease. Saudi Journal of Kidney Diseases and Transplantation Vol. 11, no. 3 (Dec. 2000), pp.334-344.
https://search.emarefa.net/detail/BIM-62611
American Medical Association (AMA)
Colattur, Shyam N.& Korbet, Stephen M.. Long-term outcome of adult onset idiopathic minimal change disease. Saudi Journal of Kidney Diseases and Transplantation. 2000. Vol. 11, no. 3, pp.334-344.
https://search.emarefa.net/detail/BIM-62611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 342-344
Record ID
BIM-62611