Quercetin-3-O-B-D-glucopyranosyl-(1 fi 6)-B-D-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells
Joint Authors
Jung, Hyun Gug
Kim, Han Hyuk
Paul, Souren
Jang, Jae Yoon
Cho, Yong Hun
Kim, Hyeon Jeong
Yu, Jae Myo
Lee, Eun Su
An, Bong Jeun
Bang, Byung Ho
Kang, Sun Chul
Source
Saudi Journal of Biological Sciences
Issue
Vol. 22, Issue 6 (30 Nov. 2015), pp.706-713, 8 p.
Publisher
Publication Date
2015-11-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
related protein-2, and tyrosinase.
Moreover, QCGG inhibited intracellular cAMP levels, cAMP response element-binding protein (CREB), and p38 MAPK expression in a-MSH-stimulated B16F10 cells.
Taken together, the suppressive effects of QCGG on melanogenesis may involve down-regulation of MITF and its downstream signaling pathway via phosphorylation of p38 MAPK and CREB along with reduced cAMP levels.
These results indicate that QCGG reduced melanin synthesis by reducing expression of tyrosine and tyrosine-related proteins via extracellular signal-related protein kinase (ERK) activation, followed by down-regulation of CREB, p38, and MITF.In this study, the effect of purified quercetin-3-O-b-D-glucopyranosyl-(1 fi 6)-b-D-glucopyranosid (QCGG) on melanogenesis was investigated.
QCGG was isolated from the calyx of a traditional Korean medicinal herb, Persimmon (Diospyros kaki).
The hypopigmentation effects of QCGG were determined by examination of cellular melanin contents, tyrosinase activity assay, cAMP assay, and Western blotting of a-MSH-stimulated B16F10 mouse melanoma cells.
Our results showed that QCGG inhibited both melanin synthesis and tyrosinase activity in a concentration- dependent manner as well as significantly reduced the expression of melanogenic proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1, tyrosinase.
American Psychological Association (APA)
Jung, Hyun Gug& Kim, Han Hyuk& Paul, Souren& Jang, Jae Yoon& Cho, Yong Hun& Kim, Hyeon Jeong…[et al.]. 2015. Quercetin-3-O-B-D-glucopyranosyl-(1 fi 6)-B-D-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells. Saudi Journal of Biological Sciences،Vol. 22, no. 6, pp.706-713.
https://search.emarefa.net/detail/BIM-628610
Modern Language Association (MLA)
Jung, Hyun Gug…[et al.]. Quercetin-3-O-B-D-glucopyranosyl-(1 fi 6)-B-D-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells. Saudi Journal of Biological Sciences Vol. 22, no. 6 (Nov. 2015), pp.706-713.
https://search.emarefa.net/detail/BIM-628610
American Medical Association (AMA)
Jung, Hyun Gug& Kim, Han Hyuk& Paul, Souren& Jang, Jae Yoon& Cho, Yong Hun& Kim, Hyeon Jeong…[et al.]. Quercetin-3-O-B-D-glucopyranosyl-(1 fi 6)-B-D-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 6, pp.706-713.
https://search.emarefa.net/detail/BIM-628610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 712-713
Record ID
BIM-628610