The spectrum of glomerulopathy in Jordan

Abstract EN

In this study, we reviewed the records and the histological findings of a total of 350 adequate native kidney biopsies at both the Jordan University Hospital (260 biopsies in the period 1986-1989) and the Jordan Hospital (90 biopsies in the period 1997-1999).

There were 187 males (53.4 %) and 163 females (46.6 %).

Their ages ranged between 12-77 years.

The nephrotic syndrome was the presenting feature in 194 (55.4 %) patients, acute renal failure in 55 (15.7 %), hematuria and / or non-nephrotic proteinuria in 45 (12.9 %), chronic renal failure in 32 (9.1 %) and hematuria alone 24 (6.9 %).

In the patients with the nephrotic syndrome, 140 (72.2 %) had primary nephrotic syndrome.

In this group membranoproliferative glomerulonephritis (MPGN) was the most common pathology and was detected in 49 patients (35 %) followed by focal segmental glomerulosclerosis (FSGS) in 38 (27.1 %).

Amyloidosis and systemic lupus erythematosus were the commonest findings among the 54 patients with secondary nephrotic syndrome (40.7 % and 38.8 % respectively).

Rapidly progressive glomerulonephritis was seen in 34.5 % of those patients presenting with acute renal failure, while FSGS was seen in 25 % of those with chronic renal failure.

Finally IgA nephropathy was the major finding among both the 45 patients with hematuria-proteinuria and the 24 patients with isolated hematuria (26.2 % and 66.6 % respectively).