Microalbuminuria and pegylated interferon in hepatitis-C patients
Joint Authors
Abd al-Muhsin, Walid Anwar
Tantawi, Tariq
Sany, Dawlah
al-Shahawi, Yasir
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 6 (31 Dec. 2015), pp.1183-1189, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
- Viruses
- Kidneys
- Diseases
- Urinary protein
- Antiviral agents
- Therapeutics
- Egypt
- Therapeutic use
- Diagnosis
- Hepatitis C
- Hepatitis C virus
Abstract EN
To determine the relation between hepatitis C virus (HCV) genotype 4 and microalbuminuria in relation to hepatic histology and viremia in the absence of cryoglobulinemia and to examine the effect of treatment on microalbuminuria, we studied 400 HCV genotype-4-infected patients who were tested for microalbuminuria, albumin creatinine ratio (ACR), urea, creatinine and estimated glomerular filtration rate (eGFR).
The parameters were measured again in the HCV patients after six months of treatment with pegylated interferon and ribavirin.
Microalbuminuria was detected in 56 (14%) HCV-positive patients.
There was a highly significant reduction in the microalbuminuria levels among the HCV-positive individuals after six months of therapy (P <0.001).
Microalbuminuria was significantly associated with older age [Odds Ratio (OR): 1.1, 95% confidence interval (CI) : 1.0–1.2, P = 0.01], elevated creatinine (OR : 0.09, 95% CI : 0.01– 0.7, P = 0.02), high modified Histological Activity Index score (OR: 1.5, 95 % CI: 1.1–1.5, P = 0.004) and increased viral load (OR: 2.8, 95 % CI: 1.1–6.6, P = 0.01).
Sustained virological response (SRV) was achieved in 272 (86 %) patients.
The individuals with SVR had lower microalbuminuria post-treatment (P = 0.56).
We conclude that HCV infection can be associated with microalbuminuria, which can be reduced by the use of a combination therapy of pegylated interferon-ribavirin.
American Psychological Association (APA)
al-Shahawi, Yasir& Sany, Dawlah& Abd al-Muhsin, Walid Anwar& Tantawi, Tariq. 2015. Microalbuminuria and pegylated interferon in hepatitis-C patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 6, pp.1183-1189.
https://search.emarefa.net/detail/BIM-629629
Modern Language Association (MLA)
al-Shahawi, Yasir…[et al.]. Microalbuminuria and pegylated interferon in hepatitis-C patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 6 (Nov. / Dec. 2015), pp.1183-1189.
https://search.emarefa.net/detail/BIM-629629
American Medical Association (AMA)
al-Shahawi, Yasir& Sany, Dawlah& Abd al-Muhsin, Walid Anwar& Tantawi, Tariq. Microalbuminuria and pegylated interferon in hepatitis-C patients. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 6, pp.1183-1189.
https://search.emarefa.net/detail/BIM-629629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1188-1189
Record ID
BIM-629629