A study of wound healing by local injection of insulin

Abstract EN

Objectives: In this prospective study we aim to demonstrate the effect of small doses of topical long acting insulin ( zink insulin ) application in wound healing.

Methods: Thirty eight patients were studied in our private out-patient clinic between the years 2009 to 2011 , long acting insulin ( zinc insulin ) was used to avoid the hypoglycemic effect of insulin .

with a mean of 6.32 ± 4.319cm.

13(34.2 %) of the wounds were infected, 18 (47.4 %) had allergy to stitches , 4(10.5 %) had unhealthy granulation tissue and 3(7.9 %) were covered with tough fibrin.

These wounds were prepared prior to the study by giving antibiotic, removing the stitches, excising bad granulation tissue and removing fibrin.

Soluble Insulin injection was prepared at a concentration of 1-Unit/10ml distilled water, then injected superficially in the inside of the wounds of the patient, and the effect was observed.

The time range of saline-insulin treated wound closure was 15 days with a mean of 7.13 ± 4.461 days.

All patients had an excellent outcome and their wounds closed in a short time without any complications.

Conclusion: Topical insulin application leads to acceleration of wound healing.

The duration of wound healing and outcomes in our study were excellent.

This depends on many factors also which should be taken seriously like wound infection of the wound and size.

Results : From a total of 38 patients, 20(52.6 %) were males and 18(47.4 %) were females.

The median age was 49 years with a mean age of 35.11±11.543 years.

There were different causes of the wounds, 21(55.3 %) patients had previous operations leading to the wound, 9(23.7 %) developed chronic wounds after burns, and 8(21.0 %) had a wound due to trauma.

The wounds were distributed in different sites of the body.

In the trunk 24(63.2 %) patients, in the extremeties 11(28.9 %) patients and in the breast 3(7.9%).

All the wounds were previously dressed with saline.

The sizes of the wounds varied, minimum wound size was 1cm and maximum was 16cm