Prevalence of the HFE gene mutation in the liver transplanted and primary hemochromatosis patients in the southern Iran
Joint Authors
Karimi, M.
Mihrabani, D.
Firoozi, M. Saber
Amirizadeh, S.
Yavarian, M.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 12, Issue 1 (30 Oct. 2010), pp.22-26, 5 p.
Publisher
Publication Date
2010-10-30
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : primary hemochromatosis is an inherited disorder.
Mutation in this gene is accompanied with iron overload in the body leading to organ failure that primarily affects liver.
Individuals with homozygote HFE gene mutation are prone to developing the end stage liver disease.
Concomitance heterozygote HFE mutation with the other hepatic risk factors may accelerate hepatic damage, leading to cirrhosis.
The aim of this study was to find out the spectrum and frequency of the HFE gene mutations in the liver transplantation (end-stage liver disease [ESLD]) candidate groups.
Methods : totally, 170 individuals were studied for HFE gene mutations including 87 ESLD patients with various etiologies from Division of Liver Transplant in Nemeses Hospital affiliated to Shiraz University of Medical Sciences.
Seventy four randomly selected healthy blood donors were evaluated as the control group, and 9 hemochromatosis patients who referred to our lab for genetic analysis due to their high serum ferritin levels and clinical diagnosis were surveyed in a period of one year.
Results : HFE gene mutation was found in 57 (~33%), 14 (~9%), and 15 (~83%) chromatids of the ESLD group, control sample, and hemochromatosis patients, respectively.
The allele frequency of H63D is about 0.085 among these people.
The HFE mutation H63D in the ESLD is significantly higher than that of the control group (W / H 63D : odds ratio 5.70, 95% CI = 2.6–12.55 ; H63D / H63D : odds ratio 6.39, 95% CI = 0.77-53.1).
Conclusion : in compliance with our previous report, the C282Y mutation is very uncommon in the southern population.
This prevalence could be due to a significant aggravating effect of H63D for liver disease in these patients and may contribute to the poor liver transplantation outcome.
American Psychological Association (APA)
Yavarian, M.& Firoozi, M. Saber& Mihrabani, D.& Amirizadeh, S.& Karimi, M.. 2010. Prevalence of the HFE gene mutation in the liver transplanted and primary hemochromatosis patients in the southern Iran. Iranian Red Crescent Medical Journal،Vol. 12, no. 1, pp.22-26.
https://search.emarefa.net/detail/BIM-63033
Modern Language Association (MLA)
Yavarian, M.…[et al.]. Prevalence of the HFE gene mutation in the liver transplanted and primary hemochromatosis patients in the southern Iran. Iranian Red Crescent Medical Journal Vol. 12, no. 1 (Oct. 2010), pp.22-26.
https://search.emarefa.net/detail/BIM-63033
American Medical Association (AMA)
Yavarian, M.& Firoozi, M. Saber& Mihrabani, D.& Amirizadeh, S.& Karimi, M.. Prevalence of the HFE gene mutation in the liver transplanted and primary hemochromatosis patients in the southern Iran. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 1, pp.22-26.
https://search.emarefa.net/detail/BIM-63033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 26-27
Record ID
BIM-63033