Synthesis and characterization of 5-(4-hydroxy-3-methoxy-phenyl)‎-3,7-dimethyl-5h-thiazolo[3,2-a]pyrimidine-2,6-dicarboxylic acid 2-ethyl ester 6-methyl ester and its 6-ethyl ester 5-naphthalene

Abstract EN

The compounds 5-(4-hydroxy-3-methoxy-phenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine- 2,6-dicarboxylic acid 2-ethyl ester 6-methyl ester (2a) and 3,7-dimethyl-5-naphthalen-1-yl- 5H-thiazolo[3,2-a]pyrimidine-2,6-dicarboxylic acid diethyl ester (2b) were synthesized by the base catalyzed cyclocondensation of 3,4-dihydropyrimidine-2-thione with ethylacetoacetate.

IR, 1H NMR, 13C NMR spectra and elemental analysis were used to characterize these compounds.

The structures were determined by single crystal X-ray diffraction.

The crystal structure is stabilized by intermolecular O–H N, C–H O, C–H p and p p weak interactions.