Effect of treatment with steroid compounds on diabetices-induce endocrinological and physiological disorders in female rats

Abstract EN

It was aiming to investigate the effect of two steroid compounds, Depo-Provera (DP) or misogyny (MG), on diabetic complications including endocrine dysfunctions such as the ovarian (estrous) cycle and pituitary-thyroid hormones, and on plasma levels of enzymes, protein fractions, bilirubin, urea, and cretonne indicative for the liver and kidney functions.

DM did not only reduce the body weight gain, but also somatic index of the ovary, thyroids, liver, and kidneys.

Either DP or MG improved the weight gain of rats, and restored the organs weights near to the normal.

The improving effect of DP was more potent.

DM reduced both total and normal estrous cycles, and increased the incidence of abnormal ones.

DP led to further decrease of complete cycles, enhancing the incidence of abnormal ones, and failed to yield normal cycles.

In a contrary, MG tended to regulate the estrous cycle of diabetic rats, where it increased total and normal cycles, and reduced the incidence of the abnormal ones.

Moreover, DM shortened the mean duration of the follicular phase at the expense of the luteal one, and it was found that MG was more effective in the regulation, where it stimulated the follicular phase and inhibited the luteal one compared to +ve diabetic rats.

DM increased the plasma levels of T3 and T4, and decreased the pituitary TSH.

DP or MG can restore the hormonal pattern close to the control.

DM decreased AST, and increased ALT and ALP, suggesting a degree of hepatic derangements.

DP exerted a limited effect in increasing of ALT in a manner less than those in +ve diabetic rats.

Whereas MG restored these enzyme levels near to the normal values; it has a remarkable effect on the amelioration of such enzyme levels.

DM decreased plasma levels of both proteins and albumin, and neither DP nor MG could reduce or improve these indices significantly.

On other side, DM enhanced the release of globulin, and either DP or MG could reduce such increase to normal.

DM may reduce A /G ratio, and either DP or MG further significantly decrease it.

DM increased the accumulation of bilirubin, urea, and cretonne in the circulation.

DP or particularly MG tended to lower the elevation of such metabolites, particularly cretonne. Taken all together, these results confirmed that DM can reduce the weight, disrupt the ovarian cycle and the thyroid function, and induce hepatic and renal derangements.

Treatment of diabetics with either DP or MG can improve the weight, regulate the ovarian and thyroid functions, normalize the blood enzymes, and can also stimulate the kidneys to excrete the metabolic wastes, suggesting the possibility of therapy of diabetics with steroid compounds that can partly contribute in the improvement of diabetic complications.