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Safe conversion to cicloral, a generic cylosporine, in both stable and De Novo renal transplant recipients
Joint Authors
Kahn, Delawir
Muller, Elmi
Pascoe, Michael
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 21, Issue 3 (30 Jun. 2010), pp.426-432, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2010-06-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Several generic cyclosporine (CsA) formulations have been developed over the last decade and are now widely available.
In 2003 our local Health Department replaced Neoral with CicloHexal for the cost benefits, and we were compelled to convert all our renal transplant recipients to the generic CsA formulation.
All renal transplant recipients were converted from Neoral to CicloHexal on a 1:1 dose basis in August/September 2003.
Study 1 constitutes the retrospective review of all stable renal transplant patients and the CsA dose, CsA level and serum creatinine were noted.
Study 2 constitutes the review of the records of de novo transplant patients inititated on CicloHexal compared to matched patients transplanted on Neoral before the conversion and the CsA dose, CsA level and serum creatinine noted (Study 2).
There was no difference in the mean CsA dose, CsA level or serum creatinine at one month before conversion (on Neoral) compared to one month after conversion (on CicloHexal) in the 117 stable renal transplant recipients.
Similarly, the mean CsA dose, CsA level and serum creatinine in de novo renal transplant recipients on Neoral (n= 26) were similar to those on CicloHexal (n= 23) at about seven and ten days postoperatively.
In conclusion both stable and de novo renal transplant patients can be safely converted from Neoral to CicloHexal on a 1:1 dose basis.
American Psychological Association (APA)
Kahn, Delawir& Muller, Elmi& Pascoe, Michael. 2010. Safe conversion to cicloral, a generic cylosporine, in both stable and De Novo renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 21, no. 3, pp.426-432.
https://search.emarefa.net/detail/BIM-63562
Modern Language Association (MLA)
Kahn, Delawir…[et al.]. Safe conversion to cicloral, a generic cylosporine, in both stable and De Novo renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation Vol. 21, no. 3 (Jun. 2010), pp.426-432.
https://search.emarefa.net/detail/BIM-63562
American Medical Association (AMA)
Kahn, Delawir& Muller, Elmi& Pascoe, Michael. Safe conversion to cicloral, a generic cylosporine, in both stable and De Novo renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation. 2010. Vol. 21, no. 3, pp.426-432.
https://search.emarefa.net/detail/BIM-63562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 432
Record ID
BIM-63562