Response to prophylactic treatment in migrainures with epileptic discharges in comparism to migrainures with out epileptic discharges

Abstract EN

Background: migraine is a neurovascular disorder some times associated with epilepsy, in this study we go further in this association and detect subclinical focal epileptic discharges in migrainures.Aim:to study the difference in response to certain prophylactic antimigraine drugs(both propranolol and amytriptylline) between migrainures with focal epileptic discharges and migrainures with out focal epileptic discharges.

Patients and methods: we studied 617 patients with migraine with frequent attaches(more than two per week) of ages between 15 and 63 years old, we divided them in to those with focal epileptic discharges and those with out focal epileptic discharges according to the EEG results, we started treatment for them using a fixed regimen (propranolol 20 mg twice daily and amytriptylline 10-25 mg once daily) and follow their response to treatment for three months.

Results: we found that 62.45% of those with out epileptic discharges responded to treatment in comparism to only 35.83% of those with epileptic discharges.

Conclusion: migraineurs with focal epileptic discharges will be less responder to prophylactic antimigraine drugs (propranolol and / or amytriptylline) than those with out focal epileptic discharges.