Synthesis, characterization of new azetidinone derivatives and evaluation of their antimicrobial activity
Other Title(s)
تحضير و تشخيص مشتقات جديدة لمركبات الازتايدينون و دراسة فعاليتها البايولوجية
Joint Authors
al-Badr, Alya Ahmad
Salman, Husam Hamzah
Ali, Mundhir Abd al-Jalil Muhammad
Source
Maisan Journal of Academic Studies
Issue
Vol. 13, Issue 24 (30 Jun. 2014), pp.1-12, 12 p.
Publisher
University of Misan Faculty of Basic Education
Publication Date
2014-06-30
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Abstract AR
تم في هذه الدراسة تحضير اثنين من المشتقات الجديدة لمركبات ال β-لاكتام من تفاعل قواعد شيف و المحضرة أيضا في هذه الدراسة مع الكلورو اسيتايل كلورايد.
حضرت قواعد شف من تفاعل 5-نايترو فورفورال مع أدوية السلفا.
تم تشخيص المركبات المحضرة باستخدام التحليل العنصري الدقيق بالإضافة لمطيافيتي الأشعة تحت الحمراء و الرنين النووي المغناطيسي.
تم أيضا دراسة الفعالية البويولوجية للمشتقات المحضرة ضد نوعين من البكتريا و نوعين من الفطريات.
أظهرت النتائج بأن المركبات المحضرة ذات فعالية جيدة مضادة للبكتريا و الفطريات مقارنة بالمركبات الدوائية القياسية المستخدمة في البحث.
Abstract EN
In the present study new azetidinone derivatives containing sulfa drug moiety have been prepared by cyclocondensation of the Schiff bases derived from sulfa drugs with chloroacetyl chloride in the presence of triethylamine.
The Schiff bases are prepared by the condensation reaction of the sulfa drug (sulfadiazine and sulfanilamide) with the 5-nitro-2-furancaroboxyaldehyde.
The structure of the azetidinons were confirmed by elemental analysis (C.
H.
N.) and FT-IR, 1H-NMR spectroscopy.
The compounds were screened for their antimicrobial activity against Staphylococcus aureus, Escherichia coli, Aspergilus niger and Aspergilus flavus.
The compounds exhibited good antimicrobial activity in comparison with standard drugs
American Psychological Association (APA)
Salman, Husam Hamzah& Ali, Mundhir Abd al-Jalil Muhammad& al-Badr, Alya Ahmad. 2014. Synthesis, characterization of new azetidinone derivatives and evaluation of their antimicrobial activity. Maisan Journal of Academic Studies،Vol. 13, no. 24, pp.1-12.
https://search.emarefa.net/detail/BIM-643078
Modern Language Association (MLA)
Salman, Husam Hamzah…[et al.]. Synthesis, characterization of new azetidinone derivatives and evaluation of their antimicrobial activity. Maisan Journal of Academic Studies Vol. 13, no. 24 (Jun. 2014), pp.1-12.
https://search.emarefa.net/detail/BIM-643078
American Medical Association (AMA)
Salman, Husam Hamzah& Ali, Mundhir Abd al-Jalil Muhammad& al-Badr, Alya Ahmad. Synthesis, characterization of new azetidinone derivatives and evaluation of their antimicrobial activity. Maisan Journal of Academic Studies. 2014. Vol. 13, no. 24, pp.1-12.
https://search.emarefa.net/detail/BIM-643078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 11-12
Record ID
BIM-643078
