Prevalence of matrix metalloproteinase-9 in breast cancer as a marker of prognosis
Other Title(s)
فحص البروتينيز المعدني الحشوي-9 (MMP-9) كمؤشر حيوي في تشخيص سرطان الثدي
Joint Authors
Ashur, Zaynah F.
Ismail, Nur H.
Majid, Iyad M.
Bakir, Wasan A.
Source
Iraqi Journal of Biotechnology
Issue
Vol. 13, Issue 2(s) (31 Dec. 2014), pp.266-272, 7 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract AR
يمثل البروتينيز المعدني الحشوي-9 انزيما مهما في عملية تحلل الغشاء القاعدي و الحشوات بين الخلايا خلال مرحلة انتشار السرطان.
هدفت هذه الدراسة لمقارنة مستوى تعبير البروتينيز 9-MMP في سرطان الثدي الغدي و الأورام المتليفة و ذلك من خلال استخدام تقنية التهجين خارج الخلايا لثلاثين نسيجا تعود إلى عينات من سرطان الثدي و أخرى طبيعية.
بينت النتائج بأن مستوى تعبير البروتينيز 9-MMP كان عاليا معنويا في عينات السرطان مقارنة مع العينات الطبيعية مما يجعل هذا البروتين مؤشر حياتي مهم في التشخيص المبكر لسرطان الثدي.
Abstract EN
Matrix metalloproteinase-9 (MMP-9) is regarded as important for degradation of the basement membrane and extracellular matrix during cancer invasion and other tissue-remodeling events.
the aim of this study is to investigate and compare the expression of MMP-9 in human breast adenocarcinoma with fibroadenoma.
In this study we evaluate the prognostic value of MMP-9, by in situ hybridization staining in a series of 30 breast cancer tissues.
Both mean percentage of MMP-9 MRNA and scoring of it،s expression in normal and cancer, showing an increased expression of MMP-9 was significantly high in tumor compared with control samples, with extensive score among breast cancer tissues.
This study shows that MMP-9 expression in breast cancer is associated with better prognosis.
American Psychological Association (APA)
Bakir, Wasan A.& Ashur, Zaynah F.& Ismail, Nur H.& Majid, Iyad M.. 2014. Prevalence of matrix metalloproteinase-9 in breast cancer as a marker of prognosis. Iraqi Journal of Biotechnology،Vol. 13, no. 2(s), pp.266-272.
https://search.emarefa.net/detail/BIM-643571
Modern Language Association (MLA)
Bakir, Wasan A.…[et al.]. Prevalence of matrix metalloproteinase-9 in breast cancer as a marker of prognosis. Iraqi Journal of Biotechnology Vol. 13, no. 2 (2014), pp.266-272.
https://search.emarefa.net/detail/BIM-643571
American Medical Association (AMA)
Bakir, Wasan A.& Ashur, Zaynah F.& Ismail, Nur H.& Majid, Iyad M.. Prevalence of matrix metalloproteinase-9 in breast cancer as a marker of prognosis. Iraqi Journal of Biotechnology. 2014. Vol. 13, no. 2(s), pp.266-272.
https://search.emarefa.net/detail/BIM-643571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 271-272
Record ID
BIM-643571
