Synthesis of some new 2-(4-Aryliminophenoxy)‎ N-Arylacetamide Via p-hydroxy benzaldehyde

Abstract EN

Chloroacetamide derivatives (2a-g) have been prepared through reaction of chloroacetyl chloride(1) (which prepared by the reaction of chloroacetic acid with thionyl chloride) with primary aromatic amines and sulfa compounds to afford compounds (2a-g) which then reacted with p-hydroxy benzaldehyde via Williamson reaction to obtaine the new compounds 2-(4-formyl phenoxy)-N-aryl acetamide (3a-g).

Finally , compounds (3a-g) will be use as a good synthon to prepare the Schiff bases represented by compounds 2-(4-aryliminophenoxy)-N-arylacetamide (4a-g).

through , reaction with some primary aromatic amine.

All the prepared compounds were investigated by the available physical and spectroscopic methods.