Nrf2 and p73 polymorphisms in Egyptian women with breast cancer
Other Title(s)
التعدد الجيني Nrf2 و الجين P73 في السيدات المصريات المصابات بسرطان الثدي
Joint Authors
Ibrahim, Iman Hasan
Atiyyah, Hanan Abd al-mawjud
Abd al-Aziz, Hibah Jamal
Kamel, Mahmud Muhammad
Source
The Egyptian Journal of Biochemistry and Molecular Biology
Issue
Vol. 33, Issue 1-2 (31 Dec. 2015), pp.82-95, 14 p.
Publisher
Egyptian Society of Biochemistry and Molecular Biology
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Topics
Abstract EN
The aim of the study was to assess the role of Nrf2 promoter and P73 G4C14 to A4T14 polymorphisms in breast cancer and the potential relation to the onset of the disease.
Eighty six female patients with breast tumor were included in this study.
Nrf2 (rs6721961) and p73 (G4A) genetic polymorphisms in promoter and exon2 region respectively were investigated using PCR-CTPP assay.
The genotype frequencies of the three genotypes of Nrf2 promoter SNP (CC, CA, AA) showed no significant difference between benign and malignant groups.
Genotype frequencies for P73 G4A SNP (GG, GA) showed no significant difference between benign and malignant groups, no patient have the AA genotype.
Regarding the onset of disease, the three Nrf2 genotypes in pre - and post-menopausal patients, showed that the distribution differ significantly in the 2 patients groups and that the AA genotype is significantly higher in the pre-menopausal patients compared to post-menopausal patients.
Nrf2 (rs6721961) AA genotype might be related to early breast cancer onset.
P73 G4A polymorphism shows no relation to both disease risk and disease onset.
Therefore Nrf2 (rs6721961) promoter genotyping might be related to the risk of pre-menopausal breast cancer.
American Psychological Association (APA)
Ibrahim, Iman Hasan& Atiyyah, Hanan Abd al-mawjud& Abd al-Aziz, Hibah Jamal& Kamel, Mahmud Muhammad. 2015. Nrf2 and p73 polymorphisms in Egyptian women with breast cancer. The Egyptian Journal of Biochemistry and Molecular Biology،Vol. 33, no. 1-2, pp.82-95.
https://search.emarefa.net/detail/BIM-644650
Modern Language Association (MLA)
Ibrahim, Iman Hasan…[et al.]. Nrf2 and p73 polymorphisms in Egyptian women with breast cancer. The Egyptian Journal of Biochemistry and Molecular Biology Vol. 33, no. 1-2 (Dec. 2015), pp.82-95.
https://search.emarefa.net/detail/BIM-644650
American Medical Association (AMA)
Ibrahim, Iman Hasan& Atiyyah, Hanan Abd al-mawjud& Abd al-Aziz, Hibah Jamal& Kamel, Mahmud Muhammad. Nrf2 and p73 polymorphisms in Egyptian women with breast cancer. The Egyptian Journal of Biochemistry and Molecular Biology. 2015. Vol. 33, no. 1-2, pp.82-95.
https://search.emarefa.net/detail/BIM-644650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 91-94
Record ID
BIM-644650