![](/images/graphics-bg.png)
Organic selenium delay liver tumor growth induced by den through maintain c-met signaling on balb-c mice
Other Title(s)
السيلنيوم العضوي له دور فعال في منعُ و تأخير سرطان الكبد الناُتج عن مادة الداي اثيل نيَتروزامين في الجرزان البيضاء
Joint Authors
al-Alfi, Muhammad Mahmud
Fudah, Ibrahim Muhammad
Hamid, Muhammad Fawzi
Source
Assiut Veterinary Medical Journal
Issue
Vol. 61, Issue 147 (31 Oct. 2015), pp.66-72, 7 p.
Publisher
Assiut University Faculty of Veterinary Medicine
Publication Date
2015-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Notably, it was found that DEN accelerate liver tumor growth through enhanced c-met signaling loss while organic selenium delayed chemical carcinogenesis through maintaining hepatocyte growth factor receptor and improving antioxidant status of treated mice.
Moreover selenium treated groups showed fewer and smaller foci and nodules than the DEN group.
At the end of the experiment no mice showed hepatocellular carcinoma (HCC) in the DEN-Se group but showed only advanced dysplasia.
While acontrol positive group which administered DEN showed hepatocellular carcinoma in all mice.
Additionally, selenium maintained liver enzymes and antioxidant liver status to basal level while DEN enhanced significant increase of liver enzymes and significant decrease of super-oxide dismutase and glutathione levels to basal level.
We conclude that selenium had an inhibitory effect on the initiation and promotion stages of DEN-induced preneoplastic foci and nodules.
Selenium also prevented progression of these nodules to HCC.
American Psychological Association (APA)
al-Alfi, Muhammad Mahmud& Fudah, Ibrahim Muhammad& Hamid, Muhammad Fawzi. 2015. Organic selenium delay liver tumor growth induced by den through maintain c-met signaling on balb-c mice. Assiut Veterinary Medical Journal،Vol. 61, no. 147, pp.66-72.
https://search.emarefa.net/detail/BIM-648583
Modern Language Association (MLA)
al-Alfi, Muhammad Mahmud…[et al.]. Organic selenium delay liver tumor growth induced by den through maintain c-met signaling on balb-c mice. Assiut Veterinary Medical Journal Vol. 61, no. 147 (Oct. 2015), pp.66-72.
https://search.emarefa.net/detail/BIM-648583
American Medical Association (AMA)
al-Alfi, Muhammad Mahmud& Fudah, Ibrahim Muhammad& Hamid, Muhammad Fawzi. Organic selenium delay liver tumor growth induced by den through maintain c-met signaling on balb-c mice. Assiut Veterinary Medical Journal. 2015. Vol. 61, no. 147, pp.66-72.
https://search.emarefa.net/detail/BIM-648583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 70-72
Record ID
BIM-648583