Does type of cardioplegia affect myocardial and cerebral outcome in pediatric open cardiac surgeries ?
Joint Authors
al-Mursi, Jamal Z.
al-Dib, Ala al-Din M.
al-Jamal, Muhammad Adil F.
Abd Allah, Hazim M.
Abu Hadid, Hani M.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 7, Issue 2 (30 Jun. 2014), pp.242-249, 8 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background A single-dose strategy for cardioplegia is desired in pediatric congenital cardiac surgery, especially in repair of complex congenital defects.
The hypothesis of this study is that a single infusion of Bretschneider HTK solution may offer myocardial and cerebral protection superior to repeated doses of a cold oxygenated blood cardioplegic solution in pediatric congenital cardiac surgery.
Patients and methods Sixty patients who underwent congenital cardiac repair using cardiopulmonary bypass were grouped randomly to receive either a single dose of Custodiol (group A) or repeated oxygenated blood cardioplegia (group B).
Echocardiography, ECG, and microscopic examination were used to evaluate left-ventricular function and structure.
Myocardial injury was assessed with creatine kinase MB and serum troponin T, whereas cerebral outcome was assessed by jugular venous oxygen saturation.
Patients were also neurologically examined and studied by brain computed tomography for gross neurological manifestation of cerebral ischemia or infarction preoperative and 2 days postoperatively.
Results Myocardial enzymes and oxygen extraction were significantly high in group B compared with group A.
Ultrastructure evaluation and cerebral outcome were significantly better in group A than in group B.
Conclusion A single dose of an HTK cardioplegic solution provides better myocardial and cerebral protection than repeated doses of oxygenated blood cardioplegia during pediatric congenital cardiac surgery.
American Psychological Association (APA)
al-Mursi, Jamal Z.& Abd Allah, Hazim M.& Abu Hadid, Hani M.& al-Jamal, Muhammad Adil F.& al-Dib, Ala al-Din M.. 2014. Does type of cardioplegia affect myocardial and cerebral outcome in pediatric open cardiac surgeries ?. Ain Shams Journal of Anesthesiology،Vol. 7, no. 2, pp.242-249.
https://search.emarefa.net/detail/BIM-649419
Modern Language Association (MLA)
al-Mursi, Jamal Z.…[et al.]. Does type of cardioplegia affect myocardial and cerebral outcome in pediatric open cardiac surgeries ?. Ain Shams Journal of Anesthesiology Vol. 7, no. 2 (Apr. / Jun. 2014), pp.242-249.
https://search.emarefa.net/detail/BIM-649419
American Medical Association (AMA)
al-Mursi, Jamal Z.& Abd Allah, Hazim M.& Abu Hadid, Hani M.& al-Jamal, Muhammad Adil F.& al-Dib, Ala al-Din M.. Does type of cardioplegia affect myocardial and cerebral outcome in pediatric open cardiac surgeries ?. Ain Shams Journal of Anesthesiology. 2014. Vol. 7, no. 2, pp.242-249.
https://search.emarefa.net/detail/BIM-649419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 248-249
Record ID
BIM-649419