Comparison of intrathecal magnesium, dexmedetomidine, or placebo combined with bupivacaine 0.5 % for patients with mild pre-eclampsia undergoing cesarean section
Joint Authors
Hamawi, Tamir Y. Elie
Muhammad, Mahmud Hasan
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 8, Issue 2 (30 Jun. 2015), pp.230-235, 6 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background Neuraxial anesthesia for pre-eclamptic patients undergoing cesarean section is a wellestablished safe and effective anesthetic technique.
Several agents had been studied as adjuvants to commonly used intrathecal drugs.
Aim The aim of this prospective, randomized, double-blinded placebo-controlled study is to compare intrathecal magnesium versus dexmedetomidine (DXM) combined with bupivacaine 0.5% for parturients with mild pre-eclampsia undergoing cesarean section in terms of duration of spinal block as a primary outcome and postoperative analgesia and incidence of intraoperative side effects as secondary outcomes.
Patients and methods Ninety pregnant women with singleton pregnancies, scheduled for elective cesarean section and diagnosed with mild pre-eclampsia, were enrolled in this prospective, randomizedcontrolled double-blind study.
Lumbar puncture was performed and then patients were allocated to three groups: group D [0.5% hyperbaric bupivacaine 2.5 ml and 0.1 ml (10 μg) preservative-free DXM]; group M [0.5% hyperbaric bupivacaine 2.5 ml and 0.1 ml preservative-free 10% magnesium sulfate (10 mg)]; and group C (0.5% hyperbaric bupivacaine 2.5 ml and preservative-free saline 0.1 ml as a control).
Duration of sensory block, motor block, maximal level of sensory block, and duration of spinal anesthesia were recorded.
The incidences of hypotension, sedation, nausea, and vomiting were noted every 15 min during surgery.
Pain was assessed using a verbal numeric scale from 0 to 10 at 2, 4, 8, 12, 18, and 24 h postoperatively.
Intramuscular diclofenac 75 mg was administered for rescue analgesia whenever the pain score was greater than 3.
Overall patient satisfaction with anesthesia and analgesia was recorded at 24 h as 1 = excellent; 2 = good; and 3 = poor.
Results The three groups were comparable with respect to patients’ demographics, gestational age, and duration of surgery.
The duration of sensory block, motor block, and spinal anesthesia were prolonged in group M (175.2 ± 19.4, 216.3 ± 12.6, and 200.3 ± 6.4 min) compared with group D (153 ± 4.78, 181.7 ± 7.8, and 160.4 ± 7 min) and group C (150.37 ± 8.8, 171 ± 8.1, and 165 ± 5.83 min), P < 0.001.
There was less ephedrine consumption in group M (7.87 ± 0.98 mg) compared with group D (12.4 ± 1.1 mg) and group C (12.3 ± 1.3 mg), P < 0.001.
The cumulative requirement of diclofenac over 24 h was signifi cantly less in group M (135.8 ± 27.7 mg) than in group D (183.3 ± 26.7 mg) and group C (187 ± 22.6 mg), P < 0.001.
Verbal numeric scale scores in the fi rst 24 h were signifi cantly higher in the control group (group C) than the other two groups.
American Psychological Association (APA)
Hamawi, Tamir Y. Elie& Muhammad, Mahmud Hasan. 2015. Comparison of intrathecal magnesium, dexmedetomidine, or placebo combined with bupivacaine 0.5 % for patients with mild pre-eclampsia undergoing cesarean section. Ain Shams Journal of Anesthesiology،Vol. 8, no. 2, pp.230-235.
https://search.emarefa.net/detail/BIM-650157
Modern Language Association (MLA)
Hamawi, Tamir Y. Elie& Muhammad, Mahmud Hasan. Comparison of intrathecal magnesium, dexmedetomidine, or placebo combined with bupivacaine 0.5 % for patients with mild pre-eclampsia undergoing cesarean section. Ain Shams Journal of Anesthesiology Vol. 8, no. 2 (Apr. / Jun. 2015), pp.230-235.
https://search.emarefa.net/detail/BIM-650157
American Medical Association (AMA)
Hamawi, Tamir Y. Elie& Muhammad, Mahmud Hasan. Comparison of intrathecal magnesium, dexmedetomidine, or placebo combined with bupivacaine 0.5 % for patients with mild pre-eclampsia undergoing cesarean section. Ain Shams Journal of Anesthesiology. 2015. Vol. 8, no. 2, pp.230-235.
https://search.emarefa.net/detail/BIM-650157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 234-235
Record ID
BIM-650157