Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation
Joint Authors
Chandak, Aruna
Ghosh, Alok
Golhar, Mayuri
Jain, Vaibhav
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 8, Issue 2 (30 Jun. 2015), pp.236-243, 8 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background The pressor response, which is part of a huge spectrum of stress responses, results from the increase in sympathetic and sympathoadrenal activity.
This study was conducted to compare the effi cacy of dexmedetomidine and fentanyl for attenuation of largyngoscopic pressor response.
Patients and methods Sixty patients of ASA I and II were randomly divided into two groups.
Group D patients received an injection of dexmedetomidine at a dose of 1 g/kg, whereas group F patients received an injection of fentanyl at a dose of 2 g/kg preoperatively over 10 min before induction of anesthesia with an injection of thiopentone and vecuronium.
After laryngoscopy, anesthesia was maintained with isofl urane (0.6% v/v)+N2O (50%)+O2 (50%).
Intraoperatively, heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure (MBP), SpO2, and ECG were recorded at the following intervals: at baseline, after drug administration (at 2, 5, and 8 min), before induction, after induction, and after laryngoscopy.
Results Dexmedetomidine signifi cantly attenuated the sympathetic response to laryngoscopy and intubation in terms of heart rate, systolic blood pressure, and diastolic blood pressure compared with fentanyl.
The total dose of thiopentone for induction of general anesthesia was signifi cantly less in the dexmedetomidine group as compared with the fentanyl group.
Incidence of bradycardia and hypotension was higher in patients of the dexmedetomidine group when compared with the fentanyl group.
Conclusion An intravenous infusion of dexmedetomidine at 1 g/kg administered 10 min before laryngoscopy and endotracheal intubation can be recommended over fentanyl at 2 g/kg to attenuate the sympathetic response to laryngoscopy and endotracheal intubation with minimal side effects.
American Psychological Association (APA)
Jain, Vaibhav& Chandak, Aruna& Ghosh, Alok& Golhar, Mayuri. 2015. Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation. Ain Shams Journal of Anesthesiology،Vol. 8, no. 2, pp.236-243.
https://search.emarefa.net/detail/BIM-650163
Modern Language Association (MLA)
Ghosh, Alok…[et al.]. Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation. Ain Shams Journal of Anesthesiology Vol. 8, no. 2 (Apr. / Jun. 2015), pp.236-243.
https://search.emarefa.net/detail/BIM-650163
American Medical Association (AMA)
Jain, Vaibhav& Chandak, Aruna& Ghosh, Alok& Golhar, Mayuri. Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation. Ain Shams Journal of Anesthesiology. 2015. Vol. 8, no. 2, pp.236-243.
https://search.emarefa.net/detail/BIM-650163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 243
Record ID
BIM-650163