Phenytoin-induced acute liver injury case report : possible drug interactions and risk factors
Joint Authors
al-Shahir, Ahmad N.
Abu al-Futuh, Sawsan
Abd Allah, Nihad
Abu al-Izz, Sali
Abd al-Tawwab, Ahmad M.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 6, Issue 3 (31 Dec. 2013), pp.329-331, 3 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Topics
Abstract EN
Phenytoin is a widely used anticonvulsant drug in the ICU that requires therapeutic drug monitoring.
It carries a major risk of dose-related toxicity because of its saturation (zero-order) pharmacokinetic.
Hepatic injury with phenytoin is common and varies from almost trivial to massive necrosis and is usually hepatocellular.
Here, we report on a 45-year-old woman who was admitted to the ICU with subarachnoid hemorrhage and developed an acute liver injury 16 days after phenytoin injection.
Phenytoin was stopped and replaced by oxcarbazepine.
Possible drug interactions and risk factors are also discussed.
American Psychological Association (APA)
Abu al-Futuh, Sawsan& Abd Allah, Nihad& Abu al-Izz, Sali& al-Shahir, Ahmad N.& Abd al-Tawwab, Ahmad M.. 2013. Phenytoin-induced acute liver injury case report : possible drug interactions and risk factors. Ain Shams Journal of Anesthesiology،Vol. 6, no. 3, pp.329-331.
https://search.emarefa.net/detail/BIM-650246
Modern Language Association (MLA)
Abu al-Futuh, Sawsan…[et al.]. Phenytoin-induced acute liver injury case report : possible drug interactions and risk factors. Ain Shams Journal of Anesthesiology Vol. 6, no. 3 (Sep. / Dec. 2013), pp.329-331.
https://search.emarefa.net/detail/BIM-650246
American Medical Association (AMA)
Abu al-Futuh, Sawsan& Abd Allah, Nihad& Abu al-Izz, Sali& al-Shahir, Ahmad N.& Abd al-Tawwab, Ahmad M.. Phenytoin-induced acute liver injury case report : possible drug interactions and risk factors. Ain Shams Journal of Anesthesiology. 2013. Vol. 6, no. 3, pp.329-331.
https://search.emarefa.net/detail/BIM-650246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 331
Record ID
BIM-650246