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comparative study between the effect of intrathecal midazolam versus intrathecal midazolam plus magnesium sulfate on the efficacy and duration of analgesia in patients undergoing cesarean section
Joint Authors
Boules, Majid L.
Butrus, Yusuf M.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 8, Issue 1 (31 Mar. 2015), pp.70-75, 6 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background Regional techniques using either epidural or intrathecal routes are currently the most popular methods of pain relief during labor and delivery.
Aim The aim of the study was to compare effi cacy and duration of analgesia produced by adding magnesium sulfate to intrathecal bupivacaine (10 mg) plus midazolam (1 mg) in patients undergoing cesarean section.
Patients and methods In our study, 60 patients aged 18–35 years of American Society of Anesthesiologists (ASA) class I and II were scheduled for a cesarian section under an intrathecal block and divided randomly into two groups: midazolam group (group M) : A total of 30 patients received 10 mg/2 ml intrathecal 0.5 % hyperbaric bupivacaine, midazolam (1 mg / 0.2 ml), and 0.8 ml normal saline and magnesium midazolam group (group MM) : A total of 30 patients received 10 mg / 2 ml intrathecal 0.5 % hyperbaric bupivacaine, midazolam (1 mg / 0.2 ml), magnesium sulfate (50 mg/0.5 ml), and 0.3 ml normal saline.
The onset and duration of both sensory and motor block, the total dose of analgesia, and adverse effects were recorded.
Results The onset of sensory block was signifi cantly delayed in the MM group compared with the M group (6.05 ± 1.1 vs.
3.5 ± 0.45 min, P = 0.024) ; the duration of sensory block was longer in the MM group compared with the M group (132.4 ± 7.8 vs.
115.3 ± 6.60 min, P = 0.018).
In addition, the onset of motor block was delayed in the MM group (7.05 ± 1.3 min) compared with the M group (5 ± 0.65 min, P = 0.028) as well as its duration (149.9 ± 8.67 vs.
126.3 ± 5.35 min, P = 0.005).
Conclusion The addition of magnesium sulfate to intrathecal bupivacaine plus midazolam led to a signifi cant delay in the onset of both sensory and motor blockade, and also prolonged their duration without side effects
American Psychological Association (APA)
Boules, Majid L.& Butrus, Yusuf M.. 2015. comparative study between the effect of intrathecal midazolam versus intrathecal midazolam plus magnesium sulfate on the efficacy and duration of analgesia in patients undergoing cesarean section. Ain Shams Journal of Anesthesiology،Vol. 8, no. 1, pp.70-75.
https://search.emarefa.net/detail/BIM-650632
Modern Language Association (MLA)
Boules, Majid L.& Butrus, Yusuf M.. comparative study between the effect of intrathecal midazolam versus intrathecal midazolam plus magnesium sulfate on the efficacy and duration of analgesia in patients undergoing cesarean section. Ain Shams Journal of Anesthesiology Vol. 8, no. 1 (Jan. / Mar. 2015), pp.70-75.
https://search.emarefa.net/detail/BIM-650632
American Medical Association (AMA)
Boules, Majid L.& Butrus, Yusuf M.. comparative study between the effect of intrathecal midazolam versus intrathecal midazolam plus magnesium sulfate on the efficacy and duration of analgesia in patients undergoing cesarean section. Ain Shams Journal of Anesthesiology. 2015. Vol. 8, no. 1, pp.70-75.
https://search.emarefa.net/detail/BIM-650632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 75
Record ID
BIM-650632