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Ultrasound-guided transversus abdominis plane block versus dexmedetomidine infusion in open ovarian cystectomy : analgesic efficacy and effect on stress response
Joint Authors
Maghawiri, Khalid M.
Rayyan, Ayman A.
al-Katib, Ala S.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 8, Issue 1 (31 Mar. 2015), pp.114-123, 10 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background Ultrasound (US)-guided transversus abdominis plane ( TAP) block has been proven to be an effective method of providing postoperative analgesia in laparotomy.
Dexmedetomidine has sedative, analgesic, sympatholytic, and amnestic properties.
In the present study, we evaluated the analgesic effi cacy and the attenuation of stress surgical response of US-guided TAP block in comparison with dexmedetomidine infusion in patients undergoing open ovarian cystectomy in a randomized, double-blinded clinical study.
Patients and methods A total of 60 patients were randomly assigned into two groups (30 in each) to be administered, before skin incision, either a combination of general anesthesia with a US-guided TAP block (TAP group), or an intraoperative intravenous infusion of dexmedetomidine ( DEX group).
In the DEX group, loading dose of 1 μg/kg of dexmedetomidine was infused over 10 min, followed by infusion of 0.2–0.6 μg/kg/h.
Measurements included hemodynamics, stress hormones, pain score, time of fi rst analgesia, and amount of pethidine during the fi rst 24 h postoperative.
Results In the DEX group, there was a signifi cant decrease in heart rate (HR) at 45, 60, and 90 min after surgical incision in comparison with preoperative HR.
In the TAP group, there was a signifi cant decrease in HR at 60 and 90 min after surgical incision in comparison with preoperative HR.
In the DEX group, there was a signifi cant decrease in mean arterial pressure at 30, 45, 60, and 90 min after surgical incision in comparison with preoperative mean arterial pressure.
The DEX group had shown a statistically signifi cant increase with regard to change in the blood level of stress hormones 12 and 24 h postoperative in comparison with the preoperative values.
There was a highly signifi cant increase in postoperative pethidine supplementation in the DEX group than in the TAP group.
There was a signifi cant difference with regard to time of the fi rst postoperative request of analgesia in the DEX group than in the TAP group.
Conclusion In open ovarian cystectomy, US-guided TAP block was comparable to dexmedetomidine infusion with regard to intraoperative hemodynamic stability and opioid requirement without change in stress response hormones.
However, TAP block provided superior analgesia when compared with dexmedetomidine infusion up to 24 h postoperatively.
American Psychological Association (APA)
Maghawiri, Khalid M.& Rayyan, Ayman A.& al-Katib, Ala S.. 2015. Ultrasound-guided transversus abdominis plane block versus dexmedetomidine infusion in open ovarian cystectomy : analgesic efficacy and effect on stress response. Ain Shams Journal of Anesthesiology،Vol. 8, no. 1, pp.114-123.
https://search.emarefa.net/detail/BIM-650908
Modern Language Association (MLA)
Maghawiri, Khalid M.…[et al.]. Ultrasound-guided transversus abdominis plane block versus dexmedetomidine infusion in open ovarian cystectomy : analgesic efficacy and effect on stress response. Ain Shams Journal of Anesthesiology Vol. 8, no. 1 (Jan. / Mar. 2015), pp.114-123.
https://search.emarefa.net/detail/BIM-650908
American Medical Association (AMA)
Maghawiri, Khalid M.& Rayyan, Ayman A.& al-Katib, Ala S.. Ultrasound-guided transversus abdominis plane block versus dexmedetomidine infusion in open ovarian cystectomy : analgesic efficacy and effect on stress response. Ain Shams Journal of Anesthesiology. 2015. Vol. 8, no. 1, pp.114-123.
https://search.emarefa.net/detail/BIM-650908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 122-123
Record ID
BIM-650908