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Dexmedetomidine versus midazolam propofol or midazolam fentanyl for conscious sedation during awake fiberoptic intubation
Joint Authors
al-Tuhami, Sana A.
Masud, Samiyah M.
Amin, Azzah A.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 6, Issue 1 (31 Jan. 2013), pp.30-37, 8 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2013-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background Awake fiberoptic intubation (AFOI) is an established technique for the management of patients with difficult airways.
A number of drugs have been described to provide sedation for this procedure.
Benzodiazepines combined with opioids or propofol are commonly used agents.
Recently, dexmedetomidine has emerged as an ideal sedative during AFOI.
Objectives To compare the efficacy and safety of dexmedetomidine as a sole sedative versus the conventionally used propofol/midazolam and fentanyl/midazolam combinations during AFOI.
Patients and methods Seventy-five patients with anticipated difficult airways who required tracheal intubation for elective surgery were enrolled and randomly allocated to one of three groups: group D (n = 25) received a dexmedetomidine infusion, group PM (n=25) received a propofol/ midazolam combination, and group FM (n = 25) received a fentanyl/midazolam combination.
The main outcome measures were fiberoptic intubating conditions and patient tolerance, which were graded using multiple scoring systems.
Other parameters including hemodynamic (mean arterial pressure and heart rate) and respiratory changes were recorded.
Results All the scores that quantified patient tolerability and the fiberoptic intubating conditions were significantly better in group D than both groups PM and FM.
Mean arterial pressure and heart rate decreased significantly during sedation in group D and group PM.
Meanwhile, there was considerable hemodynamic stability in both group D and PM during intubation.
The dexmedetomidine group showed more favorable respiratory changes than the other two groups.
Conclusion Dexmedetomidine alone appears to be a more suitable agent for sedation during AFOI compared with either propofol/midazolam or fentanyl/midazolam combinations.
American Psychological Association (APA)
Masud, Samiyah M.& al-Tuhami, Sana A.& Amin, Azzah A.. 2013. Dexmedetomidine versus midazolam propofol or midazolam fentanyl for conscious sedation during awake fiberoptic intubation. Ain Shams Journal of Anesthesiology،Vol. 6, no. 1, pp.30-37.
https://search.emarefa.net/detail/BIM-651452
Modern Language Association (MLA)
Masud, Samiyah M.…[et al.]. Dexmedetomidine versus midazolam propofol or midazolam fentanyl for conscious sedation during awake fiberoptic intubation. Ain Shams Journal of Anesthesiology Vol. 6, no. 1 (Jan. 2013), pp.30-37.
https://search.emarefa.net/detail/BIM-651452
American Medical Association (AMA)
Masud, Samiyah M.& al-Tuhami, Sana A.& Amin, Azzah A.. Dexmedetomidine versus midazolam propofol or midazolam fentanyl for conscious sedation during awake fiberoptic intubation. Ain Shams Journal of Anesthesiology. 2013. Vol. 6, no. 1, pp.30-37.
https://search.emarefa.net/detail/BIM-651452
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 37
Record ID
BIM-651452