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Toxicity of the aqueous extract of colocynth Citrullus colocynthis (L.) schrad on laboratory rat Rattus norvigicus
Other Title(s)
سمية المستخلص المائي لثمار نبات الحنظل على جرذ المعامل النرويجي
Joint Authors
Ilyas, Ihab al-Sirr Muhammad
Zayn al-Abidin, Muhammad Hamzah
Asad, Yusuf Uthman Husayn
al-Atum, al-Amin M. A.
Source
Journal of Science and Technology : in Agricultural and Veterinary Sciences
Issue
Vol. 16, Issue 1 (30 Jun. 2015), pp.57-63, 7 p.
Publisher
Sudan University of Science and Technology Deanship of Scientific Research
Publication Date
2015-06-30
Country of Publication
Sudan
No. of Pages
7
Main Subjects
Topics
Abstract EN
This study aimed at investigating the acute toxicity of the aqueous-extract of colocynth (Hanzal) Citrullus colocynthis (L.) Schrad, using albino laboratory rats Rattus norvigicus as laboratory experimental animals.
Five dosage levels were selected according to preliminary screening tests.
These were 90, 180, 225, 270 and 315 mg.
They were administered orally through intubation to each group of albino rats.
The treated rats were observed for 24 hr for acute toxicity symptoms.
Death almost occurred between 1 – 18 hrs after the treatment.
Corrected mortalities were 0, 33.3, 50, 66.7 and 100 corresponding to the above mentioned dosage levels respectively.
The mean oral LD50 was determined through probit analysis, it was found to be 2402 mg/kg body weight.
Symptoms of toxicity were severe anorexia, diarrhoea, difficulty in breathing, inability to stand upright, collapse, muscles atrophy and death.
American Psychological Association (APA)
Ilyas, Ihab al-Sirr Muhammad& Asad, Yusuf Uthman Husayn& al-Atum, al-Amin M. A.& Zayn al-Abidin, Muhammad Hamzah. 2015. Toxicity of the aqueous extract of colocynth Citrullus colocynthis (L.) schrad on laboratory rat Rattus norvigicus. Journal of Science and Technology : in Agricultural and Veterinary Sciences،Vol. 16, no. 1, pp.57-63.
https://search.emarefa.net/detail/BIM-651550
Modern Language Association (MLA)
Ilyas, Ihab al-Sirr Muhammad…[et al.]. Toxicity of the aqueous extract of colocynth Citrullus colocynthis (L.) schrad on laboratory rat Rattus norvigicus. Journal of Science and Technology : in Agricultural and Veterinary Sciences Vol. 16, no. 1 (Jun. 2015), pp.57-63.
https://search.emarefa.net/detail/BIM-651550
American Medical Association (AMA)
Ilyas, Ihab al-Sirr Muhammad& Asad, Yusuf Uthman Husayn& al-Atum, al-Amin M. A.& Zayn al-Abidin, Muhammad Hamzah. Toxicity of the aqueous extract of colocynth Citrullus colocynthis (L.) schrad on laboratory rat Rattus norvigicus. Journal of Science and Technology : in Agricultural and Veterinary Sciences. 2015. Vol. 16, no. 1, pp.57-63.
https://search.emarefa.net/detail/BIM-651550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 62
Record ID
BIM-651550