Insertion and deletion polymorphism in the alpha-2B adrenoceptor gene in pregnant women ripens gestational diabetes mellitus
Joint Authors
Khan, Umran Ali
Abu Talib, Zaynab
al-Harbi, Khalid K.
Muhammad, Arif A.
al-Hakim, Malak Muhammad
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 1 (31 Jan. 2016), pp.128-134, 7 p.
Publisher
Publication Date
2016-01-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
There are no earlier studies that reported the association of the 12Glu9 polymorphism in the alpha-2B adrenoceptor (ADRA2B) gene with gestational diabetes mellitus (GDM).
We examined the potential association between the ADRA2B gene insertion/deletion (I/D) polymorphism in the Saudi population with GDM.
Pregnant women with GDM have been reported to exhibit the same susceptibility as that observed in type 2 diabetes mellitus (T2DM).
We have selected I/D polymorphism of the ADRA2B gene located in chromosome 2q11.1 that has been extensively related to T2DM and cardiovascular diseases.
This case–control study was conducted with 200 GDM and 300 non-GDM pregnant women.
Genotyping of I/D polymorphism was performed by conventional PCR method.
Biochemical analyses were found to be significantly different between GDM and non- GDM subjects (p < 0.05).
Genotype (ID + DD vs II, p = 0.0002) and allele (D vs I, p = 0.0002) frequencies of the 12Glu9 polymorphism were found to be statistically significant.
However, a significant difference was found between allele and genotypes of I/D polymorphism of the ADRA2B gene or the clinical characteristics of the subjects.
Our results obtained in this study indicate the ADRA2B gene in the Saudi women was associated with the development of GDM.
ª 2014 The Authors.
Production and hosting by Elsevier B.V.
on behalf of King Saud University.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
American Psychological Association (APA)
al-Hakim, Malak Muhammad& Abu Talib, Zaynab& al-Harbi, Khalid K.& Khan, Umran Ali& Muhammad, Arif A.. 2016. Insertion and deletion polymorphism in the alpha-2B adrenoceptor gene in pregnant women ripens gestational diabetes mellitus. Saudi Journal of Biological Sciences،Vol. 23, no. 1, pp.128-134.
https://search.emarefa.net/detail/BIM-652226
Modern Language Association (MLA)
al-Harbi, Khalid K.…[et al.]. Insertion and deletion polymorphism in the alpha-2B adrenoceptor gene in pregnant women ripens gestational diabetes mellitus. Saudi Journal of Biological Sciences Vol. 23, no. 1 (Jan. 2016), pp.128-134.
https://search.emarefa.net/detail/BIM-652226
American Medical Association (AMA)
al-Hakim, Malak Muhammad& Abu Talib, Zaynab& al-Harbi, Khalid K.& Khan, Umran Ali& Muhammad, Arif A.. Insertion and deletion polymorphism in the alpha-2B adrenoceptor gene in pregnant women ripens gestational diabetes mellitus. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 1, pp.128-134.
https://search.emarefa.net/detail/BIM-652226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 133-134
Record ID
BIM-652226