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Effect of pentoxifylline administration on an experimental rat model of femur fracture healing with intramedullary fixation
Joint Authors
Farhani, Muhammad Mahdi Vashghani
Farhani, Rida Masteri
Mostafavinia, Ataroalsadat
Abbasyan, Muhammad Rida
Pouriran, Ramin
Noruzian, Muhammad
Ghoreishi, Sayyid Kamran
Aryan, Arifi
Bayat, Muhammad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 17, Issue 12 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Publication Date
2015-12-31
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Globally, musculoskeletal injuries comprise a major public health problem that contributes to a large burden of disability and suffering.
Pentoxifylline (PTX) has been originally used as a hemorheologic drug to treat intermittent claudication.
Previous test tube and in vivo studies reported the beneficial effects of PTX on bony tissue.
Objectives : This study aims to evaluate the effects of different dosages of PTX on biomechanical properties that occur during the late phase of the fracture healing process following a complete femoral osteotomy in a rat model.
We applied intramedullary pin fixation as the treatment of choice.
Materials and Methods : This experimental study was conducted at the Shahid Beheshti University of Medical Sciences, Tehran, Iran.
We used the simple random technique to divide 35 female rats into five groups.
Group 1 received intraperitoneal (i.p.) PTX (50 mg/kg, once daily) injections, starting 15 days before surgery, and group 2, group 3, and group 4 received 50 mg / kg, 100 mg/kg, and 200 mg/kg i.p.
PTX injections, respectively, once daily after surgery.
All animals across groups received treatment for six weeks (until sacrificed).
Complete surgical transverse osteotomy was performed in the right femur of all rats.
At six weeks after surgery, the femurs were subjected to a three-point bending test.
Results : Daily administration of 50 mg/kg PTX (groups 1 and 2) decreased the high stress load in repairing osteotomized femurs when compared with the control group.
The highest dose of PTX (200 mg/kg) significantly increased the high stress load when compared with the control group (P = 0.030), group 1 (P = 0.023), group 2 (P = 0.008), and group 3 (P = 0.010), per the LSD findings.
Conclusions : Treatment with 200 mg/kg PTX accelerated fracture healing when compared with the control group.
American Psychological Association (APA)
Farhani, Muhammad Mahdi Vashghani& Farhani, Rida Masteri& Mostafavinia, Ataroalsadat& Abbasyan, Muhammad Rida& Pouriran, Ramin& Noruzian, Muhammad…[et al.]. 2015. Effect of pentoxifylline administration on an experimental rat model of femur fracture healing with intramedullary fixation. Iranian Red Crescent Medical Journal،Vol. 17, no. 12, pp.1-8.
https://search.emarefa.net/detail/BIM-652630
Modern Language Association (MLA)
Farhani, Muhammad Mahdi Vashghani…[et al.]. Effect of pentoxifylline administration on an experimental rat model of femur fracture healing with intramedullary fixation. Iranian Red Crescent Medical Journal Vol. 17, no. 12 (Dec. 2015), pp.1-8.
https://search.emarefa.net/detail/BIM-652630
American Medical Association (AMA)
Farhani, Muhammad Mahdi Vashghani& Farhani, Rida Masteri& Mostafavinia, Ataroalsadat& Abbasyan, Muhammad Rida& Pouriran, Ramin& Noruzian, Muhammad…[et al.]. Effect of pentoxifylline administration on an experimental rat model of femur fracture healing with intramedullary fixation. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 12, pp.1-8.
https://search.emarefa.net/detail/BIM-652630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-652630