Effects of coriandrum sativum syrup on migraine : a randomized, triple-blind, placebo-controlled trial
Joint Authors
Zadah, Husayn Rida
Amin, Ghulam
Ghubadi, Ali
Mirzaei, Zahrah
Minaei, Baqir
Ghorbanifar, Zahrah
Kasmaei, Husayn Delavar
Zayeri, Farid
Kamali, Sayyid Hamid
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 1 (31 Jan. 2016), pp.1-7, 7 p.
Publisher
Publication Date
2016-01-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Migraine is one of the most common and debilitating neurological problems.
Although numerous preventive drugs are used to treat migraine, their complications are unavoidable.
Application of herbal medicine, especially well-known medicinal plants, to treatment of chronic diseases, like migraine, could be effective.
Coriandrum sativum L.
(C.
sativum) fruit is one of the most commonly prescribed herbs in Persian medicine, which has been used to treat headache.
Objectives : This study was designed to evaluate the effects of C.
sativum syrup on duration, severity and frequency of migraine.
Patients and Methods: A total of 68 migraineurs, who had the eligibility criteria, according to international headache society diagnostic criteria, were randomly assigned to intervention group (n = 34) or control group (n = 34).
In addition to 500 mg of sodium valproate per day, in intervention group, they received 15 mL of Coriander fruit syrup and 15 mL of placebo syrup, in control group, three times a day, during a month.
The subjects were followed for clinical efficacy at weeks 1, 2, 3 and 4.
The number of migraine attacks per week, as well as the duration and severity of attacks, were evaluated.
Results : Of 68 patients randomized, 66 were included in analysis.
The generalized estimating equations analysis showed that the Coriander fruit syrup decreased duration, severity and frequency of migraine, in the intervention group (P < 0.001).
To be more precise, the mean migraine duration, severity and frequency, in the intervention group, were 5.7 hours, 3.65 units and about 50% less than control group, respectively.
Conclusions : Results of this study showed that C.
sativum fruit is efficient in reduction of the duration and frequency of migraine attacks and in diminishing pain degree
American Psychological Association (APA)
Kasmaei, Husayn Delavar& Ghorbanifar, Zahrah& Zayeri, Farid& Minaei, Baqir& Kamali, Sayyid Hamid& Zadah, Husayn Rida…[et al.]. 2016. Effects of coriandrum sativum syrup on migraine : a randomized, triple-blind, placebo-controlled trial. Iranian Red Crescent Medical Journal،Vol. 18, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-653248
Modern Language Association (MLA)
Kasmaei, Husayn Delavar…[et al.]. Effects of coriandrum sativum syrup on migraine : a randomized, triple-blind, placebo-controlled trial. Iranian Red Crescent Medical Journal Vol. 18, no. 1 (Jan. 2016), pp.1-7.
https://search.emarefa.net/detail/BIM-653248
American Medical Association (AMA)
Kasmaei, Husayn Delavar& Ghorbanifar, Zahrah& Zayeri, Farid& Minaei, Baqir& Kamali, Sayyid Hamid& Zadah, Husayn Rida…[et al.]. Effects of coriandrum sativum syrup on migraine : a randomized, triple-blind, placebo-controlled trial. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-653248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-653248