The effect of addition of different doses of ondansetron to lidocaine as a component of intravenous regional anesthesia : a randomized double-blinded controlled study
Author
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 7, Issue 4 (31 Dec. 2014), pp.545-549, 5 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
The aim of this study was to evaluate and compare the analgesic effect of adding two different doses (4or 8 mg) of ondansetron to lidocaine for intravenous regional anesthesia (IVRA).
Patients and methods Ninety-nine patients were randomly assigned into three groups.
IVRA was achieved with lidocaine 3 mg/kg 0.5% (C group) (n = 33), lidocaine 3 mg/kg 0.5% plus 4 mg ondansetron (O1 group) (n = 33) or lidocaine 3 mg/kg 0.5% plus 8 mg ondansetron (O2 group) (n = 33).
Times of onset and offset of sensory and motor blockade and the time of tourniquet pain were recorded.
Postoperative visual analogue scale, time to fi rst dose, and total amount of supplementary analgesia (diclofenac) were recorded.
Results Signifi cantly shorter onset times and longer recovery times of sensory and motor block were recorded in groups O1 and O2 compared with group C (P < 0.05) with no signifi cant difference between groups O1 and O2.
Delayed onset of tourniquet pain occurred in groups O1 and O2 compared with group C (P < 0.05) with a signifi cant difference between groups O1 and O2.
Eighteen patients required intraoperative fentanyl to control tourniquet pain in group C compared with 10 patients in group O1 and three patients in group O2, respectively.
A signifi cantly lower postoperative visual analogue scale score, a longer time to fi rst dose and lower consumption of diclofenac were recorded in groups O1 and O2 compared with group C with a signifi cant difference between groups O1 and O2.
No adverse effects were noted in any patients.
Conclusion Addition of ondansetron to lidocaine enhanced the performance of lidocaine when used in IVRA, prolonged postoperative analgesia and reduced intraoperative and postoperative analgesia.
However, adding 8 mg ondansetron to lidocaine provided better analgesia than 4 mg.
American Psychological Association (APA)
al-Bahnasawy, Nahlah S.. 2014. The effect of addition of different doses of ondansetron to lidocaine as a component of intravenous regional anesthesia : a randomized double-blinded controlled study. Ain Shams Journal of Anesthesiology،Vol. 7, no. 4, pp.545-549.
https://search.emarefa.net/detail/BIM-653665
Modern Language Association (MLA)
al-Bahnasawy, Nahlah S.. The effect of addition of different doses of ondansetron to lidocaine as a component of intravenous regional anesthesia : a randomized double-blinded controlled study. Ain Shams Journal of Anesthesiology Vol. 7, no. 4 (Oct. / Dec. 2014), pp.545-549.
https://search.emarefa.net/detail/BIM-653665
American Medical Association (AMA)
al-Bahnasawy, Nahlah S.. The effect of addition of different doses of ondansetron to lidocaine as a component of intravenous regional anesthesia : a randomized double-blinded controlled study. Ain Shams Journal of Anesthesiology. 2014. Vol. 7, no. 4, pp.545-549.
https://search.emarefa.net/detail/BIM-653665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 548-549
Record ID
BIM-653665