Assessment the immunohistochemically expression of Cathepsin D in Iraqi patients with colorectal carcinoma

Abstract EN

In the current study hundred ten of Iraqi patients with colorectal tumors were studied to evaluate the expression of Cathepsin D using Tissue microarray-Immunohistochemisty (TMA-IHC) technique.

Of them, Ninety cases had colorectal carcinoma, and twenty had benign tumors.

A group of twenty cases of non-specific colitis and other twenty colonic biopsies without significant pathology were also studied.

Results revealed high expression of Cathepsin D in tumors (96.7 % of malignant cases, 80 % of adenomas) versus 30 % of colitis.

As well high significant differences (P < 0.001) in the expression of CathepsinD in different tumor types (adenocarcinoma and mucinous carcinoma), tumor stages and grades.