The immunological effect of a gleevec drug as tyrosin kinase inhibitor in auto-immune thyroid peroxidase in Iraqi patients with chronic myeloid leukemia
Other Title(s)
التأثير المناعي لعقار الكليفيك المثبط للتايروسين كاينيز في أنزيم الثايرويد بيروكسيديز المناعي الذاتي في المرضى العراقيين المصابين بابيضاض النخاع المزمن
Joint Authors
Yasin, Yusra Ghayth
Muhammad, Haydar Jasim
Ali, Ikhlas Nuri
Source
Issue
Vol. 56, Issue 4C (31 Dec. 2015), pp.3399-3404, 6 p.
Publisher
University of Baghdad College of Science
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
A gleevec drug a tyrosine kinase inhibitor that targets the so-called Philadelphia chromosome that characteristic of chronic myeloid leukemia (CML) which has been widely used in treatment of several hematological malignancies, and there is concern about the long-term immune effects of its use.
Autoimmune disorders in patients treated with gleevec drug may be related to the direct immune modulating properties or may be linked to a possible toxic effect in target organs, triggering autoimmunity diseases.
The study described the development of symptomatic autoimmune thyroid peroxidase antibodies (TPO) in 51 patients with CML compared with 10 subjects as healthy control.
The samples collected from Iraqi National Center for Research and Treatment of Hematological Diseases/University of Al-Mustansiryiah.
Epidemiological data such as age, sex and cure period were recorded for all of the patients.
The range age of the patients were (16-70) years male and female with a cure period (8 months to 10 years) in chronic treatment with recombinant a gleevec drug.
The samples tested for anti-TPO by using Enzyme Linked Immune Sorbent Assay (ELISA) which revealed significant differences (p<0.05) between control and patients.
The patient's samples diagnosed for chronic myelogenous leukemia according to clinical physical examinations, Real-time polymerase chain reaction (RT-PCR) for detection quantification of mRNA chimerical gene bcr/abl (M-bcr) and mRNA gene/abl and by Fluorescence in Situ Hybridization (FISH) techniques in the clinical material.
The aim of the study was to test the possible association of the generation of autoimmune disease on thyroid peroxidase by the effect of gleevec drug in patients with CML
American Psychological Association (APA)
Muhammad, Haydar Jasim& Ali, Ikhlas Nuri& Yasin, Yusra Ghayth. 2015. The immunological effect of a gleevec drug as tyrosin kinase inhibitor in auto-immune thyroid peroxidase in Iraqi patients with chronic myeloid leukemia. Iraqi Journal of Science،Vol. 56, no. 4C, pp.3399-3404.
https://search.emarefa.net/detail/BIM-653806
Modern Language Association (MLA)
Muhammad, Haydar Jasim…[et al.]. The immunological effect of a gleevec drug as tyrosin kinase inhibitor in auto-immune thyroid peroxidase in Iraqi patients with chronic myeloid leukemia. Iraqi Journal of Science Vol. 56, no. 4C (2015), pp.3399-3404.
https://search.emarefa.net/detail/BIM-653806
American Medical Association (AMA)
Muhammad, Haydar Jasim& Ali, Ikhlas Nuri& Yasin, Yusra Ghayth. The immunological effect of a gleevec drug as tyrosin kinase inhibitor in auto-immune thyroid peroxidase in Iraqi patients with chronic myeloid leukemia. Iraqi Journal of Science. 2015. Vol. 56, no. 4C, pp.3399-3404.
https://search.emarefa.net/detail/BIM-653806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3402-3404
Record ID
BIM-653806