The spectrophotometric determination of famotidine drug via coupling with diazotized metochlopramide hydrochloride
Other Title(s)
التقدير الطيفي لدواء الفاموتيدين عن طريق الازدواج مع الميتوكلوبرامايد هيدروكلورايد المؤزوت
Joint Authors
al-Abayj, Muayyad Qasim
Hadi, Anfal Jalal
Muhammad, Suad Salman
Source
Issue
Vol. 12, Issue 4 (31 Dec. 2015), pp.730-739, 10 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Chemistry
Topics
Abstract EN
A new, simple and sensitive spectrophotometric method was described for the determination of famotidine (FAM) as a pure material and in pharmaceutical formulation.
This method was based on diazotization and coupling reaction between famotidine and diazotized solution of metochlopramide hydrochloride (DMPH) in the presence of phosphate buffer solution to give a compound of azo dye having orange color soluble in water with high absorptivity at a wave length of 478 nm.
The data shows that FAM and DMPH combine in the molar ratio of 1:1 at PH 7.0 .The method obeys Beer's law over concentration range of 1-40 μg.ml-1 of famotidine with a correlation coefficient of 0.9955 and a detection limit of 0.10 μg.ml-1.
The apparent molar absorptivity referred to famotidine has been found to be 2.0 x 104 L.
mol-1cm.
-1.
The proposed method was applied successfully to the assay of famotidine in pharmaceutical preparation.
American Psychological Association (APA)
al-Abayj, Muayyad Qasim& Muhammad, Suad Salman& Hadi, Anfal Jalal. 2015. The spectrophotometric determination of famotidine drug via coupling with diazotized metochlopramide hydrochloride. Baghdad Science Journal،Vol. 12, no. 4, pp.730-739.
https://search.emarefa.net/detail/BIM-654397
Modern Language Association (MLA)
al-Abayj, Muayyad Qasim…[et al.]. The spectrophotometric determination of famotidine drug via coupling with diazotized metochlopramide hydrochloride. Baghdad Science Journal Vol. 12, no. 4 (2015), pp.730-739.
https://search.emarefa.net/detail/BIM-654397
American Medical Association (AMA)
al-Abayj, Muayyad Qasim& Muhammad, Suad Salman& Hadi, Anfal Jalal. The spectrophotometric determination of famotidine drug via coupling with diazotized metochlopramide hydrochloride. Baghdad Science Journal. 2015. Vol. 12, no. 4, pp.730-739.
https://search.emarefa.net/detail/BIM-654397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 736-738
Record ID
BIM-654397