AXIN2 is associated with papillary thyroid carcinoma
Joint Authors
Lin, Xuejun
Yan, Kangkang
Zhao, Longya
Yu, Qiong
Li, Shuang
Liu, Xiaodong
Liu, Xin
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 2 (28 Feb. 2016), pp.1-3, 3 p.
Publisher
Publication Date
2016-02-28
Country of Publication
United Arab Emirates
No. of Pages
3
Main Subjects
Topics
Abstract EN
Findings of recent studies have demonstrated a rapid increase of the incidence of papillary thyroid carcinoma (PTC), which accounts for nearly 80% of thyroid cancers.
Objectives: The aim of this study was to explore the association between AXIN2 gene polymorphism and papillary thyroid carcinoma (PTC).
Patients and Methods: 106 blood samples (56 PTC patients and 50 healthy controls) were drawn from China-Japan Union Hospital in Jilin province, China, during October 2010 to March 2011.
A case-control study was designed to examine the association between AXIN2 and PTC.
Seven tag single nucleotide polymorphisms (tag SNPs) in AXIN2 were selected and genotyped.
Frequencies of different genotypes and alleles were analyzed between the patients and the controls, using the R × C column contingency table χ2 test.
The possible association of haplotypes constructed by the combined effects of two or more loci with PTC was analyzed through the UNPHASED 3.1.4 program.
Results: Rs11655966, rs3923086 and rs7591 of AXIN2 showed significant associations with PTC (P < 0.05).
The result of haplotypes analysis showed that rs11655966-rs3923086-rs4791169 had statistically significant differences between the two groups (P < 0.05).
Conclusions: Together with the functions of the target genes, we further elucidated that AXIN2 is associated with papillary thyroid carcinoma in the Chinese Han population.
American Psychological Association (APA)
Liu, Xin& Li, Shuang& Lin, Xuejun& Yan, Kangkang& Zhao, Longya& Yu, Qiong…[et al.]. 2016. AXIN2 is associated with papillary thyroid carcinoma. Iranian Red Crescent Medical Journal،Vol. 18, no. 2, pp.1-3.
https://search.emarefa.net/detail/BIM-654692
Modern Language Association (MLA)
Liu, Xin…[et al.]. AXIN2 is associated with papillary thyroid carcinoma. Iranian Red Crescent Medical Journal Vol. 18, no. 2 (Feb. 2016), pp.1-3.
https://search.emarefa.net/detail/BIM-654692
American Medical Association (AMA)
Liu, Xin& Li, Shuang& Lin, Xuejun& Yan, Kangkang& Zhao, Longya& Yu, Qiong…[et al.]. AXIN2 is associated with papillary thyroid carcinoma. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 2, pp.1-3.
https://search.emarefa.net/detail/BIM-654692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3
Record ID
BIM-654692