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A review of antifungal peptides: basis to new era of antifungal drugs
Other Title(s)
مضادات الفطريات الببتيدية : عصر جديد من العقاقير المضادة للفطريات
Author
Source
Jordan Journal of Pharmaceutical Sciences
Issue
Vol. 9, Issue 1 (31 Jan. 2016), pp.51-75, 25 p.
Publisher
University of Jordan Deanship of Academic Research (DAR)
Publication Date
2016-01-31
Country of Publication
Jordan
No. of Pages
25
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract EN
The limited arsenal of antifungal drugs coupled with the growing number of drug resistant isolates of Yeast pathogens stresses the need for the development of new antifungal agents with new mechanisms of action.
Antimicrobial peptides, an active arm of the innate immunity, represent the natural arsenal against pathogens including the yeast.
This review is focused on studying the biophysical prosperities (net charge, stereospecificty, conformation, amphipathicity, hydrophobicity, and length) of the peptides that exhibit antifungal activity enclosed within the antimicrobial peptides database till September/2015.
Studying these peptides may be the key for discovering and developing of new potent antifungal agents as they have served as models in drug discovery.
Furthermore, the review discusses the main obstacles and barriers -specifically the salt sensitivity- that prevents antifungal peptides from becoming successful drug stories.
Proposed solutions from industry and nature are also discussed.
This review serves as a potential base for utilizing antifungal peptides in drug discovery.
American Psychological Association (APA)
al-Akkam, Yazan. 2016. A review of antifungal peptides: basis to new era of antifungal drugs. Jordan Journal of Pharmaceutical Sciences،Vol. 9, no. 1, pp.51-75.
https://search.emarefa.net/detail/BIM-654995
Modern Language Association (MLA)
al-Akkam, Yazan. A review of antifungal peptides: basis to new era of antifungal drugs. Jordan Journal of Pharmaceutical Sciences Vol. 9, no. 1 (2016), pp.51-75.
https://search.emarefa.net/detail/BIM-654995
American Medical Association (AMA)
al-Akkam, Yazan. A review of antifungal peptides: basis to new era of antifungal drugs. Jordan Journal of Pharmaceutical Sciences. 2016. Vol. 9, no. 1, pp.51-75.
https://search.emarefa.net/detail/BIM-654995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 64-74
Record ID
BIM-654995