Pathogenetics : an introductory review
Author
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 17, Issue 1 (31 Jan. 2016), pp.1-23, 23 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Topics
- Biology
- Embryology
- Genetics
- Chromosomes
- Biological adaptation
- Medicine
- Diseases
- Preventive medicine
- Genetic disorders
Abstract EN
Pathogenetics refers to studying the different aspects of initiation/development/progres sion and pathogenesis of genetic defects.
It comprises the study of mutagens or factors capable of affecting the structural integrity of the genetic material leading to mutational changes that, in the majority of cases, result in harmful effects due to the resulting disturbances of functions of mutated components of the genome.
The study of mutagens depicts different types of mutagenic factors, their nature, their classification according to their effects on the genetic material and their different modes of action.
The study of mutation involves different types of mutations classified according to various parameters, e.g.
magnitude, severity, target of mutational event as well as its nature, which can be classified, in turn, according to whether it is spontaneous or induced, static or dynamic, somatic or germinal mutation etc.
Finally, pathogenetics comprises studying and delineating the different and innumerable pathophysiological alterations and pathogenetic mechanisms that are directly and indirectly involved in, and leading to, the development of genetic disorders, coupled with a parallel study of various anti-mutation mechanisms that play critical roles in minimizing the drastic effects of mutational events on the genetic material and in effective protection against the development of these diseases.
American Psychological Association (APA)
Salim, Muhammad Sad Zaghlul. 2016. Pathogenetics : an introductory review. The Egyptian Journal of Medical Human Genetics،Vol. 17, no. 1, pp.1-23.
https://search.emarefa.net/detail/BIM-655068
Modern Language Association (MLA)
Salim, Muhammad Sad Zaghlul. Pathogenetics : an introductory review. The Egyptian Journal of Medical Human Genetics Vol. 17, no. 1 (Jan. 2016), pp.1-23.
https://search.emarefa.net/detail/BIM-655068
American Medical Association (AMA)
Salim, Muhammad Sad Zaghlul. Pathogenetics : an introductory review. The Egyptian Journal of Medical Human Genetics. 2016. Vol. 17, no. 1, pp.1-23.
https://search.emarefa.net/detail/BIM-655068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 23
Record ID
BIM-655068