Apolipoprotein E gene polymorphism in Egyptian acute coronary syndrome patients
Joint Authors
Mahmud, Ayidah A.
Yusuf, Layla M.
Zaki, Nayil Abd al-Hamid
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 17, Issue 1 (31 Jan. 2016), pp.99-103, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background: Apolipoprotein E (apo E) gene polymorphism was found to be associated with coronary artery disease in several studies.
In this investigation, we aimed to study the association between apo E gene polymorphism and acute coronary syndrome in Egyptian population.
Subjects and methods: The study included 200 patients with acute coronary syndrome (myocardial infarction and unstable angina), and 100 healthy controls.
Anthropometric, clinical and lipid profile parameters were evaluated.
Apo E genotyping was carried out using sequence-specific-primer (SSP)-PCR methodology.
Results: Є3/4 genotype frequency was higher in the patients than in the controls (P <0.05), while Є2/3 genotype frequency was elevated in the controls than in the patients (P < 0.05).
In addition, the frequency of Є4 isoform was higher in the patients compared to the controls (P <0.001).
Patients with Є3/4 and Є4/4 genotypes had significantly higher total cholesterol and low density lipoprotein cholesterol, and lower triglyceride levels than those with Є3/3 genotype.
No significant differences in apo E genotype distribution were found between myocardial infarction and unstable angina patients.
Conclusion: Apo E gene polymorphism had a role in acute coronary syndrome, possibly through affecting plasma lipid parameters.
American Psychological Association (APA)
Mahmud, Ayidah A.& Yusuf, Layla M.& Zaki, Nayil Abd al-Hamid. 2016. Apolipoprotein E gene polymorphism in Egyptian acute coronary syndrome patients. The Egyptian Journal of Medical Human Genetics،Vol. 17, no. 1, pp.99-103.
https://search.emarefa.net/detail/BIM-655190
Modern Language Association (MLA)
Mahmud, Ayidah A.…[et al.]. Apolipoprotein E gene polymorphism in Egyptian acute coronary syndrome patients. The Egyptian Journal of Medical Human Genetics Vol. 17, no. 1 (Jan. 2016), pp.99-103.
https://search.emarefa.net/detail/BIM-655190
American Medical Association (AMA)
Mahmud, Ayidah A.& Yusuf, Layla M.& Zaki, Nayil Abd al-Hamid. Apolipoprotein E gene polymorphism in Egyptian acute coronary syndrome patients. The Egyptian Journal of Medical Human Genetics. 2016. Vol. 17, no. 1, pp.99-103.
https://search.emarefa.net/detail/BIM-655190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 102-103
Record ID
BIM-655190