Exploring the link between VDR rs2228570 and uterine leiomyoma in Iranian women
Author
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 17, Issue 1 (31 Jan. 2016), pp.115-118, 4 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Topics
Abstract EN
Evidences are growing toward an inhibitory role of vitamin D3 in uterine leiomyoma pathogenesis.
Uterine leiomyoma commonly affects women of reproductive age and is referred to as one of the most common indications for hysterectomy, worldwide.
The effects of vitamin D are mediated through the vitamin D receptor.
A single nucleotide polymorphism of the VDR gene results in longer protein with decreased activity.
The present study has focused on the distribution of FokI polymorphism in Iranian patients with uterine leiomyoma.
Using the PCR-RFLP method 45 cases and 53 controls were assessed.
The results demonstrated a correlation between VDR TT genotype and uterine leiomyoma by Odds Ratio of 1.886 (CI, .767–4.640).
The examination of heterozygous CT genotype also showed the same result by Odds Ratio of 1.875 (CI, .629–5.590).
This study lends support for an increased risk of uterine leiomyoma associated with the VDR rs2228570 polymorphism.
To the best of our knowledge this is the first report regarding VDR FokI polymorphism in leiomyoma patients.
American Psychological Association (APA)
Shahbazi, Shirin. 2016. Exploring the link between VDR rs2228570 and uterine leiomyoma in Iranian women. The Egyptian Journal of Medical Human Genetics،Vol. 17, no. 1, pp.115-118.
https://search.emarefa.net/detail/BIM-655213
Modern Language Association (MLA)
Shahbazi, Shirin. Exploring the link between VDR rs2228570 and uterine leiomyoma in Iranian women. The Egyptian Journal of Medical Human Genetics Vol. 17, no. 1 (Jan. 2016), pp.115-118.
https://search.emarefa.net/detail/BIM-655213
American Medical Association (AMA)
Shahbazi, Shirin. Exploring the link between VDR rs2228570 and uterine leiomyoma in Iranian women. The Egyptian Journal of Medical Human Genetics. 2016. Vol. 17, no. 1, pp.115-118.
https://search.emarefa.net/detail/BIM-655213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 117-118
Record ID
BIM-655213