Transdermal nitroglycerine as a coadjuvant to intrathecal nalbuphine with bupivacaine in lower abdominal surgery
Joint Authors
Muhammad, Hatim Sabir
Gad, Gad Sayyid
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 8, Issue 4 (31 Dec. 2015), pp.617-622, 6 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : The purpose of this study was to evaluate the effect of transdermal nitroglycerine patch as a coadjuvant to intrathecal nalbuphine with bupivacaine in patients undergoing lower abdominal surgery.
Patients and methods A total of 120 patients (ASA I or II) were randomized into two equal groups in this double-blind, placebo-controlled trial.
The control group (group C) received intrathecal 0.5% hyperbaric bupivacaine 15 mg (3 ml) plus 0.8 mg (0.4 ml) preservative-free nalbuphine plus transdermal placebo patch, and the study group (group NG) received intrathecal 0.5% hyperbaric bupivacaine 15 mg (3 ml) plus 0.8 mg (0.4 ml) preservative-free nalbuphine plus transdermal nitroglycerine patch (5 mg).
The transdermal patch (either nitroglycerine or placebo) was applied on the chest 20 min after spinal injection.
Pain intensity, hemodynamics, and adverse effects were evaluated.
Results Patients in group NG had longer duration of effective analgesia with subsequent longer time for the first rescue analgesic (482.6 ± 16.3 min) compared with group C (334.2 ± 15.6 min) (P < 0.05).
Moreover, group NG required less rescue analgesics in 24 h compared with group C (P < 0.05) and had lesser overall 24-h pain visual analogue scale scores.
The incidence of perioperative adverse effects was similar between the two groups (P > 0.05).
Conclusion Transdermal nitroglycerine (5 mg) significantly prolonged the analgesic effect of intrathecal nalbuphine and provided effective postoperative analgesia after lower abdominal surgery.
American Psychological Association (APA)
Muhammad, Hatim Sabir& Gad, Gad Sayyid. 2015. Transdermal nitroglycerine as a coadjuvant to intrathecal nalbuphine with bupivacaine in lower abdominal surgery. Ain Shams Journal of Anesthesiology،Vol. 8, no. 4, pp.617-622.
https://search.emarefa.net/detail/BIM-655485
Modern Language Association (MLA)
Muhammad, Hatim Sabir& Gad, Gad Sayyid. Transdermal nitroglycerine as a coadjuvant to intrathecal nalbuphine with bupivacaine in lower abdominal surgery. Ain Shams Journal of Anesthesiology Vol. 8, no. 4 (Oct. / Dec. 2015), pp.617-622.
https://search.emarefa.net/detail/BIM-655485
American Medical Association (AMA)
Muhammad, Hatim Sabir& Gad, Gad Sayyid. Transdermal nitroglycerine as a coadjuvant to intrathecal nalbuphine with bupivacaine in lower abdominal surgery. Ain Shams Journal of Anesthesiology. 2015. Vol. 8, no. 4, pp.617-622.
https://search.emarefa.net/detail/BIM-655485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 621-622
Record ID
BIM-655485