Multiple myeloma : diagnosis and management issues in patients with pre-existing chronic kidney disease
Joint Authors
Vadlamudi, Srilatha
Annapareddy, Siva Nagendra Reddy
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 1 (29 Feb. 2016), pp.9-14, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-02-29
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Multiple myeloma is one of the most common malignancies encountered in clinical practice.
Renal involvement in myeloma is a well-recognized entity.
Although rare, another special situation that a nephrologist can encounter is myeloma occurring in a patient with preexisting chronic kidney disease (CKD) due to other etiologies.
Anemia, bone pains and hypercalcemia, which commonly indicate the diagnosis of myeloma in the general population, are not useful in the presence of CKD.
The sensitivity and specificity of serum free light chain assay is decreased in the presence of renal failure.
Chemotherapy-related adverse effects are high compared with that in patients without CKD; this is attributed to the decreased clearance of drugs and the additive effect of chemotherapy-related adverse effects to the complications of CKD.
Autologous and allogenic bone marrow transplantation can be attempted in this group of patients with non-myeloablative-conditioning regimens.
Combined bone marrow and renal transplantation remains a viable option in this group of patients to increase life expectancy and quality of life.
American Psychological Association (APA)
Vadlamudi, Srilatha& Annapareddy, Siva Nagendra Reddy. 2016. Multiple myeloma : diagnosis and management issues in patients with pre-existing chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-655768
Modern Language Association (MLA)
Vadlamudi, Srilatha& Annapareddy, Siva Nagendra Reddy. Multiple myeloma : diagnosis and management issues in patients with pre-existing chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 1 (Jan. / Feb. 2016), pp.9-14.
https://search.emarefa.net/detail/BIM-655768
American Medical Association (AMA)
Vadlamudi, Srilatha& Annapareddy, Siva Nagendra Reddy. Multiple myeloma : diagnosis and management issues in patients with pre-existing chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-655768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14
Record ID
BIM-655768