Assay of urinary protein-bound sialic acid can differentiate steroid-sensitive nephrotic syndrome from steroid-resistant cases
Joint Authors
Gopal, Niranjan
Koner, Bidhan Chandra
Bhattacharjee, Atanu
Bhat, Vishnu
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 1 (29 Feb. 2016), pp.37-40, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-02-29
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
- Kidneys
- Biochemistry
- Lipids
- Antibodies
- Diseases
- Amino compounds
- Urine analysis
- Mannose
- Nephrotic syndrome
- Steroids
- Sialic acids
- Protein binding
Abstract EN
The protein selectivity index as measured from the ratio of urinary immunoglobulin to albumin failed to differentiate between steroid-sensitive (SS) and steroid-resistant (SR) cases of nephrotic syndrome (NS).
Sialic acid contributes negative charges to many plasma proteins.
The negative charge is a determinant of protein excretion rate.
The prognostic significance of assay of urinary excretion of protein-bound sialic acid in NS has not been evaluated.
Hence, the present study was designed to evaluate whether measurement of urinary protein - bound sialic acid (UPBSA) can be used as a marker to differentiate SS from SR cases of NS.
The urine samples of 70 (47 SS and 23 SR) pediatric NS children were assayed for UPBSA by Aminoff’s method.
The levels were compared and the receiver–operator curve was drawn to determine the optimum cutoff point to differentiate among the groups before starting the therapy.
The excretion of UPBSA in SR cases of NS was significantly higher than that of SS cases (P <0.05).
The optimum cutoff limit for UPBSA was 2.71 μg/mg of proteins with 75% sensitivity and 75.5% specificity for differentiating SS cases from SR cases (area under the plasma– concentration time curve = 0.814, P = 0.009).
We conclude that UPBSA can differentiate SR cases from SS cases of NS in pediatric patients and may help in predicting the response to steroid therapy.
American Psychological Association (APA)
Gopal, Niranjan& Koner, Bidhan Chandra& Bhattacharjee, Atanu& Bhat, Vishnu. 2016. Assay of urinary protein-bound sialic acid can differentiate steroid-sensitive nephrotic syndrome from steroid-resistant cases. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 1, pp.37-40.
https://search.emarefa.net/detail/BIM-655810
Modern Language Association (MLA)
Gopal, Niranjan…[et al.]. Assay of urinary protein-bound sialic acid can differentiate steroid-sensitive nephrotic syndrome from steroid-resistant cases. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 1 (Jan. / Feb. 2016), pp.37-40.
https://search.emarefa.net/detail/BIM-655810
American Medical Association (AMA)
Gopal, Niranjan& Koner, Bidhan Chandra& Bhattacharjee, Atanu& Bhat, Vishnu. Assay of urinary protein-bound sialic acid can differentiate steroid-sensitive nephrotic syndrome from steroid-resistant cases. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 1, pp.37-40.
https://search.emarefa.net/detail/BIM-655810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 40
Record ID
BIM-655810