Evaluation of immune response to hepatitis B vaccine among malnourished children in Yemen
Joint Authors
al-Sami, Fuad A. A.
al-Agib, Atif A.
al-Sonboli, Najla A.
al-Kumaim, Fawzi A.
al-Sayyid, Nadir S.
al-Dubibi, Abd al-Malak T.
Source
Yemeni Journal for Medical Sciences
Issue
Vol. 2015, Issue 9 (31 Dec. 2015), pp.14-21, 8 p.
Publisher
University of Science and Technology
Publication Date
2015-12-31
Country of Publication
Yemen
No. of Pages
8
Main Subjects
Topics
Abstract EN
Objectives: To determine the coverage rate of hepatitis B virus (HBV) vaccine and to evaluate the immune response to HBV vaccine by measuring hepatitis B surface antibody (anti-HBs) among malnourished un-der-five-year old children.
Methods: A cross-sectional study was conducted in two tertiary hospitals in Yemen; Al-Sabeen Maternity and Child Hospital in Sana’a and the Yemeni-Swedish Hospital in Taiz city in the period from March 2014 to Dec.
2014.
The target population was malnourished children aged from 6 to 59 months old with a histo-ry of three HBV vaccine doses in infancy.
According to the World Health Organization’s definition of malnu-trition, 121 malnourished children were enrolled in the study.
Data of malnourished children were collect-ed using a pre-designed, pre-tested questionnaire.
Two milliliters of venous blood were taken, and anti-HBs was then tested by enzyme linked immunosorbent assay.
An anti-HBs level of at least 10 IU/L was considered a successful response to the vaccine.
Results: The coverage rate of HBV vaccine among malnourished children was 89.3%, being higher among girls (52.1%) than boys (37.2%).
Response to HBV vaccine (≥10 IU/L) was observed in 72.2% (78/108) of children while 27.8% (30/108) of children failed to respond to the vaccine, with a statistically significant difference (p <0.001).
Conclusions: A good HBV vaccine coverage rate was found among malnourished Yemeni children, with a moderate rate of protection.
Therefore, re-vaccination or administration of booster doses to a substantial proportion of vaccinated children should be considered.
American Psychological Association (APA)
al-Sami, Fuad A. A.& al-Agib, Atif A.& al-Sonboli, Najla A.& al-Kumaim, Fawzi A.& al-Sayyid, Nadir S.& al-Dubibi, Abd al-Malak T.. 2015. Evaluation of immune response to hepatitis B vaccine among malnourished children in Yemen. Yemeni Journal for Medical Sciences،Vol. 2015, no. 9, pp.14-21.
https://search.emarefa.net/detail/BIM-655819
Modern Language Association (MLA)
al-Sami, Fuad A. A.…[et al.]. Evaluation of immune response to hepatitis B vaccine among malnourished children in Yemen. Yemeni Journal for Medical Sciences No. 9 (2015), pp.14-21.
https://search.emarefa.net/detail/BIM-655819
American Medical Association (AMA)
al-Sami, Fuad A. A.& al-Agib, Atif A.& al-Sonboli, Najla A.& al-Kumaim, Fawzi A.& al-Sayyid, Nadir S.& al-Dubibi, Abd al-Malak T.. Evaluation of immune response to hepatitis B vaccine among malnourished children in Yemen. Yemeni Journal for Medical Sciences. 2015. Vol. 2015, no. 9, pp.14-21.
https://search.emarefa.net/detail/BIM-655819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 19-21
Record ID
BIM-655819