Plasma neutrophil gelatinase-associated lipocalin as a marker for the prediction of worsening renal function in children hospitalized for acute heart failure
Joint Authors
Raslan, Layla
Mursi, Said
Hasan, Bashir
al-Sharawi, Sahar A.
Khalifah, Najla
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 1 (29 Feb. 2016), pp.49-54, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-02-29
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
- Children
- Heart
- Kidneys
- Diseases
- Penal functions
- Medical examinations
- Cardiac arrests
- Heart failure
- Lipocalin
- Electrocardiography
Abstract EN
Acute heart failure (AHF) is frequently associated with worsening renal function in adult patients.
Neutrophil gelatinase-associated lipocalin (NGAL) serves as an early marker for acute renal tubular injury.
To assess the role of plasma NGAL in predicting worsening renal function (WRF) in children with AHF, we studied 30 children hospitalized for AHF; children with history of chronic renal disease or on nephrotoxic drugs were excluded.
Twenty age- and sex-matched healthy children were included in the study as a control group.
Echocardiographic examination was performed on admission.
Blood urea nitrogen (BUN), serum creatinine, estimated glomerular filtration rate (eGFR) and plasma NGAL levels were measured on admission and 72 h later.
Seventeen (56.6%) patients developed WRF within the three-day follow-up period.
At presentation, plasma NGAL level was significantly elevated in children who developed WRF.
Admission plasma NGAL level correlated with renal parameters (BUN, creatinine and eGFR) as well as with left ventricular systolic parameters (ejection fraction and fractional shortening).
For prediction of WRF, admission plasma, NGAL level > 27.5μg/L had sensitivity and specificity of 90 % and 68 %, respectively.
The area under the receiver–operator curve was higher for NGAL (0.869) than for BUN (0.569) or eGFR (0.684).
We conclude that admission plasma NGAL level can predict WRF in children hospitalized for AHF.
American Psychological Association (APA)
al-Sharawi, Sahar A.& Raslan, Layla& Mursi, Said& Hasan, Bashir& Khalifah, Najla. 2016. Plasma neutrophil gelatinase-associated lipocalin as a marker for the prediction of worsening renal function in children hospitalized for acute heart failure. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 1, pp.49-54.
https://search.emarefa.net/detail/BIM-655837
Modern Language Association (MLA)
al-Sharawi, Sahar A.…[et al.]. Plasma neutrophil gelatinase-associated lipocalin as a marker for the prediction of worsening renal function in children hospitalized for acute heart failure. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 1 (Jan. / Feb. 2016), pp.49-54.
https://search.emarefa.net/detail/BIM-655837
American Medical Association (AMA)
al-Sharawi, Sahar A.& Raslan, Layla& Mursi, Said& Hasan, Bashir& Khalifah, Najla. Plasma neutrophil gelatinase-associated lipocalin as a marker for the prediction of worsening renal function in children hospitalized for acute heart failure. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 1, pp.49-54.
https://search.emarefa.net/detail/BIM-655837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 54
Record ID
BIM-655837