Levels of incretin hormones in subjects with type 2 diabetes in different grads of BMI
Joint Authors
Ibrahim, isra Habib
Zaydan, Kamil Haydar
Wtwt, Mushtaq Abd al-Hamid
Source
Issue
Vol. 12, Issue 4 (31 Dec. 2015), pp.925-933, 9 p.
Publisher
University of Babylon College of Medicine
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
Incretins are gut hormones that potentiate insulin secretion after meal ingestion in a glucose-dependent manner.
There are different types of incretin hormones like GLP-1, GLP-2 and GIP.
DPP-IV is the enzyme that deactivate incretin hormone in the blood.
The aim of this study was to evaluate the relationship between obesity and incretin hormones in patients with type 2 diabetes.The study was included (107) patients : (62) males and (45) females from Al-Hussein Medical City in Karbala province and Marjan Medical City in Babylon province.
The control for this study was (32) healthy subjects: (14) males and (18) females.BMI, Waist circumference, blood pressure , HbA1c, lipid profile, AIP, GLP-1, GLP-2 , GIP and DPP-Iv were measured to all patients and control.The resultsshow significant decrease in GLP-1 (P=0.018) and GLP-2 (P=0.028) and there was no differences in GIP (P=0.74) in patients group in comparison also there was significant increase in DPP-IV (P<0.001) in patients group in comparison with control group.According to BMI grades there was some decrease in GLP-1 and GLP-2 in obese subjects but there was no differences in GIP in comparison with lean control group.
Also there was significant increase in DPP-IV in obese patients in comparison with lean control.
We conclude that the decrease in incretin hormones may come mostly from the increase in DPP-IV enzyme that degrade them in the blood quickly and according to the relation with obesity, DPP-IV enzyme increase significantly in obese diabetic patients in comparison with healthy lean subjects.
American Psychological Association (APA)
Ibrahim, isra Habib& Zaydan, Kamil Haydar& Wtwt, Mushtaq Abd al-Hamid. 2015. Levels of incretin hormones in subjects with type 2 diabetes in different grads of BMI. Medical Journal of Babylon،Vol. 12, no. 4, pp.925-933.
https://search.emarefa.net/detail/BIM-656332
Modern Language Association (MLA)
Ibrahim, isra Habib…[et al.]. Levels of incretin hormones in subjects with type 2 diabetes in different grads of BMI. Medical Journal of Babylon Vol. 12, no. 4 (2015), pp.925-933.
https://search.emarefa.net/detail/BIM-656332
American Medical Association (AMA)
Ibrahim, isra Habib& Zaydan, Kamil Haydar& Wtwt, Mushtaq Abd al-Hamid. Levels of incretin hormones in subjects with type 2 diabetes in different grads of BMI. Medical Journal of Babylon. 2015. Vol. 12, no. 4, pp.925-933.
https://search.emarefa.net/detail/BIM-656332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 931-933
Record ID
BIM-656332