The relationship between oxidative stress and osteopontin levels in diabetic patient with acute coronary syndrome

Abstract EN

This study was performed to determine osteopontin levels in sera of diabetic patients having acute coronary syndrome and finding the relationship betweenosteopontin and oxidative stress in the corresponding patients .A case-controlled study for 60Iraqi diabetic patients (33male and 27 female)with acute coronary syndrome (STEMI and NSTEMI) and 20 diabetic patients without myocardial infraction were selectedforthisstudy.

Besides,Forty healthy subjects served as control group.The serum levels of Osteopontin (OPN),HbA1c,SOD,CAT and Malondialdehyde (MDA) were determined for the corresponding patients.The result obtained were compared with those 40 subject(20male and 20 female) who are apparently healthy (control group).All the selected patients were non -smokers,non –hypertensive and have no inflammatory disease which may affected the results of the measured parameters.

Osteopontin levels were significantly increasedin patientswith DM,STEMI and NSTEMIcompared to the controls.

The levels of MDA and HbA1Cin the patients were significantlyhigher compared to the controls whileSOD ,CATwere significantly lower compared to the controls, and a significant positive was found between osteopontin,HbA1C and MDA and negative correlation was found with SOD and CAT levels.The increase Osteopentin levels inrelevance to oxidative stress and HbA1C level may indicate the role of hyperglycemia in the induction of this acute inflammatory marker which can be considered as a prognostic indicator of diabetic complications especially diabetic patients with MI.