Evaluation of N terminal-Pro B natriuretic peptide in patients with renal dysfunction

Abstract EN

Natriuretic peptides and N terminal natriuretic peptide are peptide secreted from cardian atrium in response to stretch in cardiac muscle and considered marker in cardiac dysfunction , this study aiming to evaluate the level of NT-pro BNP in patients suffered from kidney failure .

This study were established on patient suffering from renal dysfunction who were attended .nephrology unit in Merjan Teaching Hospital in Babylon city .All patients were undergone complete laboratory and clinical examination to establish diagnosis of renal impairment and degree of renal dysfunction as blood urea and creatinine and estimation of hemoglobin level for diagnosis of anemia .

This study confirmed on patients with chronic renal failure and highlighted on the relationship between renal dysfunction and level of NT-proBNP.

Serum NT-proBNP were analysed through ELISA technique among patients with CRF mean and standard deviation of level among patients and control groups were149 ± 36.5 u unit/ml ±,36± 6.5u unit/ml respectively and comparism mean of NT-proBNP between patients and control group was indicated that there is significant difference between two groups at p value< 0.05 as analysed by students t test .

The study reveals there is positive correlation between duration of renal dysfunction and level of NT-proBNP .

The study revealed there is no effect of gender on NT-pro BNP .

Conclusion :- NT-pro BNP excretion is mainly by kidney and it is level disturbed by renal dysfunction and we considered it as marker for evaluation the relationship between renal and cardiac function and the degree of effecting of kidney on cardiac function in renal failure condition .