Bacterial evaluation and some allergic mediators of chronic rhino sinusitis with nasal polyps

Abstract EN

Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a disorder characterized by persistent eosinophilic Th2 inflammation with sinonasal microbial colonization.

It has been postulated that a compromised local mucosal immune response and microbial by-product like super-antigen underlies disease pathogenesis The affected sinuses fluid swabs and blood samples were collected from 50 a CRSwNP patients to isolate associated bacterial species and to measure serum IL-4 and total IgE and IgG levels.

The same sample were collected from health subject as a control study.

The sinonasal tract was colonized by S.aureus H.influenzae S.pneumoniae P.aeruginosa Morexella.catarrhalis S.pygenes S.intermedius, where the high prevalence rate was 34% of S.aureus , while the low prevalence rate was 2% of S.

intermedius.

ELISA revealed an elevation of serum IL-4, and total IgE and IgG levels in the CRSwNP patients compared with the control subject.

Bacterial colonization in CRSwNp is implicated with pathgenesis of this disease.

The high levels of serum IL- 4 and total IgE and IgG which were synthesized locally in the mucosa and diffuse to the blood , serve as an indicator of eosinophilic Th2- inflammation disorder.

of CRSwNP