Relationship between serum lipoprotein ratios and insulin resistance in Iraqi women with type II DM

Abstract EN

Type 2 diabetes confers an increased morbidity and mortality dueto macrovascular complicationssuch as CVDfor which dyslipidemia is themajor contributor.

This study was designed toexplore the role of non- HDLcandlipoprotein ratios as CVD riskmarker in diabetic population.

It was acase –control study , 68 female uncontrolled (HbA1c ≥ 6.5) diabetic were selected, 34 were diabetic who were treatment(Goup A) and 34 werediabetic without treatment (Group B)and 34 were non-diabetic subjects as control group .

The lipidprofile including TC, TG and HDLc were measured and calculation of lipoprotein ratios.Lipoprotein ratios were significantly higher in group A, Non-HDL(P<0.001), TC/HDL and TG/HDL(P < 0.01), LDL/HDL(P<0.05) In group B; Non-HDLc(P<0.01), TC/HDL, TG/HDL and LDL/HDL(P < 0.05) in contrast tocontrols.

There is significantly positive correlation of TG/HDLc, TC/HDLc, LDL/HDLc and Non-HDLc with HOMA-IR in group A and in group B.

Lipoprotein ratio provide a simple means of identifying insulin resistance which could be used as a possible risk factor of CVD in uncontrolledtype 2 diabetic