Polymorphism of the insertion deletion angiotensin converting enzyme (ace) gene and hypertension in a population from Erbil City
Joint Authors
Mustafa, Suhad A.
Abd al-Wahid, Muhsin J.
Amin, Nizar A.
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 27, Issue 6 (31 Dec. 2015), pp.41-46, 6 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Hypertension is a major global problem results from the combined effects of genes, environment, lifestyle and the interactions of these factors.
Genetic variations of angiotensin I-converting enzyme ACE gene may play a role in the development of human essential hypertension.
In this study, the association between ACE I/D polymorphism and hypertension was evaluated by determine the distribution of genotypes and alleles frequency of ACE gene in 123 volunteers, 50 normal (21 males and 29 females) and 73 hypertensive (21 males and 52 females) in Erbil city.
The ACE DD genotype (50%vs 24.1%) in female was found to be significantly associated with hypertension (P=0.02) and the odd ratio was (OR= 3.14: 95% CI; 1.15-8.62)which indicated that the odds of hypertensive is about three times higher in DD genotype compered to control (RR= 2.16,95% CI;1.05-4.5) in females, whereas ACE ID heterozygotes were significantly more frequent in controls (47.6 % vs.
19% P=0.04) for male only which indicated that this genotype associated with decrease in the risk of having hypertension (OR=0.28:95% CI; 0.65-1.04) for males only.
American Psychological Association (APA)
Mustafa, Suhad A.& Abd al-Wahid, Muhsin J.& Amin, Nizar A.. 2015. Polymorphism of the insertion deletion angiotensin converting enzyme (ace) gene and hypertension in a population from Erbil City. ZANCO Journal of Pure and Applied Sciences،Vol. 27, no. 6, pp.41-46.
https://search.emarefa.net/detail/BIM-656691
Modern Language Association (MLA)
Mustafa, Suhad A.…[et al.]. Polymorphism of the insertion deletion angiotensin converting enzyme (ace) gene and hypertension in a population from Erbil City. ZANCO Journal of Pure and Applied Sciences Vol. 27, no. 6 (2015), pp.41-46.
https://search.emarefa.net/detail/BIM-656691
American Medical Association (AMA)
Mustafa, Suhad A.& Abd al-Wahid, Muhsin J.& Amin, Nizar A.. Polymorphism of the insertion deletion angiotensin converting enzyme (ace) gene and hypertension in a population from Erbil City. ZANCO Journal of Pure and Applied Sciences. 2015. Vol. 27, no. 6, pp.41-46.
https://search.emarefa.net/detail/BIM-656691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 45-46
Record ID
BIM-656691