The study of Diabetic nephropathy disease and relashionshipe with GSTM1and GSTT1 genes and the risk factor of smoking of patients in the province of Thi-Qar
Other Title(s)
دراسة مرض اعتلال الكلى السكري و علاقته بفقد جينات ال GSTM1 and GSTT1 و عامل خطورة التدخين لدى المرضى في محافظة ذي قار
Joint Authors
al-Rikabi, Hasan Raysan
Faysal, Huda Tahir
Source
Issue
Vol. 9, Issue 3 (30 Sep. 2014), pp.63-73, 11 p.
Publisher
University of Thi-Qar Research and Development Department
Publication Date
2014-09-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
- Smoking
- Nucleic acids
- Diabetes
- Iraq
- Dhi Qar
- Genes
- Molecular genetics
- Genetic aspects
- Diagnosis
- Health aspects
Abstract EN
The experimental group of this study contains 100 blood samples collected from patients with diabetic nephropathy infraction admitted to AL-Hussein Teaching Hospital and the educational center of the kidney industrial and civil medical laboratories in the province of Thi-Qar who ranged in age between 9-89 years old and 90 samples for people who are not infected with diabetic nephropathy infraction as a comparison group .
the samples have been preserved in tube containers with EDTA under tempreture (-20o) DNA was extracted and then GSTM1 and GSTT1 were amplified which are responsible for detoxification and Albumin as an internal control.
The results showed that 71% of the patients were living urban areas while 29% of the inhabitants of rural areas, the results also showed the proportion of patients who are smokers 34% and the non- smokers are 66% and patients who have family history are 51% compare to 49% for those who does not have family history and the results showed 39% of infected males and 61% infected females.
The results showed that the existence of the effect of smoking and lost GSTT1 gene is increasing the risk of diabetic nephropathy infraction by five times (OR= 5.037;95%CI= 1.242-20.426) as well as at the loss of two genes together GSTM1and GSTT1 as much as four times (OR= 4.308;95%CI= 0.444- 41.817) compared with the comparison group and the loss of together genes GSTM1,GSTT1 has contributed to increase the risk by (OR= 1.982;95%CI= 0.625-6.297).
American Psychological Association (APA)
al-Rikabi, Hasan Raysan& Faysal, Huda Tahir. 2014. The study of Diabetic nephropathy disease and relashionshipe with GSTM1and GSTT1 genes and the risk factor of smoking of patients in the province of Thi-Qar. University of Thi-Qar Journal،Vol. 9, no. 3, pp.63-73.
https://search.emarefa.net/detail/BIM-657274
Modern Language Association (MLA)
al-Rikabi, Hasan Raysan& Faysal, Huda Tahir. The study of Diabetic nephropathy disease and relashionshipe with GSTM1and GSTT1 genes and the risk factor of smoking of patients in the province of Thi-Qar. University of Thi-Qar Journal Vol. 9, no. 3 (Sep. 2014), pp.63-73.
https://search.emarefa.net/detail/BIM-657274
American Medical Association (AMA)
al-Rikabi, Hasan Raysan& Faysal, Huda Tahir. The study of Diabetic nephropathy disease and relashionshipe with GSTM1and GSTT1 genes and the risk factor of smoking of patients in the province of Thi-Qar. University of Thi-Qar Journal. 2014. Vol. 9, no. 3, pp.63-73.
https://search.emarefa.net/detail/BIM-657274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 71-72
Record ID
BIM-657274